| Also known as: |
CD163 |
| Other names: |
CD163 molecule, Hemoglobin scavenger receptor, Scavenger receptor cysteine-rich type 1 protein M130, hemoglobin scavenger receptor, macrophage-associated antigen, scavenger receptor cysteine-rich type 1 protein M130, scavenger receptor cysteine-rich type 1 protein M130 isoform a |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD163 |
| Other gene names: |
CD163, M130, M130, MM130, sCD163, CD163 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
EDHu-1 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD163 is not expressed by resting peripheral blood leucocytes, Clone EDHu-1 is reported to inhibit the binding of haptoglobin, Cysteine-rich, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Truncation mutation analysis demonstrates binding of EDHu-1 occurs via the N-terminal region of CD163 containing the first three scavenger receptor, a 130-140kD glycoprotein expressed by tissue macrophages, but expression may be induced on monocytes by culture in dexamethasone, cleavage of this domain at the major cleavage site abrogates binding to the N-terminal fragment, the third domain being critical as, CD163 Recognises the human CD163 cell surface antigen, haemoglobin to CD163 Removal of sodium azide is recommended prior to use in functional studies |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunohistology - Paraffin (IHC), Western Blot (WB), Immunohistology - Frozen (IHC) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD163 |
| Short name: |
MOUSE Anti-HUMAN CD163 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD163 molecule (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD163 and IDBG-16292 and ENSG00000177575 and 9332, CD163 and IDBG-639861 and ENSBTAG00000019669 and 533844, Cd163 and IDBG-186721 and ENSMUSG00000008845 and 93671, Extracellular, M130 and MM130, protein binding, this GO :0005044 and scavenger receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0006953 and acute-phase response and biological process this GO :0016020 and membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component, this GO :0005044 : scavenger receptor activity, this GO :0005044 : scavenger receptor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, CD163 molecule |
| Identity: |
1631 |
| Gene: |
CD163 |
More about : CD163 |
| Long gene name: |
CD163 molecule |
| Synonyms gene name: |
CD163 antigen |
| Synonyms: |
M130 MM130 SCARI1 |
| Locus: |
12p13, 31 |
| Discovery year: |
2000-01-18 |
| GenBank acession: |
Z22968 |
| Entrez gene record: |
9332 |
| Pubmed identfication: |
10403791 8370408 |
| RefSeq identity: |
NM_004244 NM_203416 |
| Classification: |
CD molecules Scavenger receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000168353 |