| Also known as: |
CD247 |
| Other names: |
CD247 antigen, CD247 molecule, CD3Z antigen, CD3zeta chain, T-cell antigen receptor complex, T-cell receptor T3 zeta chain, T-cell receptor T3 zeta chain, T-cell surface glycoprotein CD3 zeta chain, T-cell surface glycoprotein CD3 zeta chain, TCR zeta chain, zeta polypeptide (TiT3 complex), zeta subunit, zeta subunit of CD3, T-cell surface glycoprotein CD3 zeta chain isoform 2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD247 |
| Other gene names: |
CD247, CD3-ZETA, CD3H, CD3Q, CD3Z, CD3Z, T3Z, T3Z, TCRZ, TCRZ, CD247 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
G3 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
A novel monoclonal antibody, Both the CD3 and TCR zeta subunits are proposed to be responsible for the intracellular signal transduction events, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, T cell activation through the TCR induces cellular differentiation and/or proliferation and the production of lymphokines and cytokines, The antibody is capable of precipitating both non-phosphorylated and tyrosine phosphorylated TCR zeta chain, This particular antibody might cross react with speacies outside of the listed ones, all of which are required for efficient surface expression, has been developed that is specific for the TCR zeta chain subunit (CD247), named G3, CD247 The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma/delta/eta and zeta subunits |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD247 |
| Short name: |
MOUSE Anti-HUMAN CD247 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD247 molecule (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD247 and IDBG-104547 and ENSG00000198821 and 919, CD247 and IDBG-629556 and ENSBTAG00000012700 and 281056, CD3-ZETA and CD3H and CD3Q and CD3Z and IMD25 and T3Z and TCRZ, Cd247 and IDBG-202777 and ENSMUSG00000005763 and 12503, Plasma membranes, protein homodimerization activity, this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0031295 and T cell costimulation and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042101 and T cell receptor complex and cellular component this GO :0042105 and alpha-beta T cell receptor complex and cellular component this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0045087 and innate immune response and biological process this GO :0050690 and regulation of defense response to virus by virus and biological process this GO :0050776 and regulation of immune response and biological process this GO :0050852 and T cell receptor signaling pathway and biological process, this GO :0004888 : transmembrane signaling receptor activity, this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005515 : protein binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity, this GO :0005515 : protein binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, CD247 molecule |
| Identity: |
1677 |
| Gene: |
CD247 |
More about : CD247 |
| Long gene name: |
CD247 molecule |
| Synonyms gene: |
CD3Z |
| Synonyms gene name: |
CD3z antigen, zeta polypeptide (TiT3 complex) CD247 antigen |
| Synonyms: |
CD3H CD3Q |
| Locus: |
1q24, 2 |
| Discovery year: |
1989-04-06 |
| GenBank acession: |
BC025703 |
| Entrez gene record: |
919 |
| Pubmed identfication: |
2974162 |
| RefSeq identity: |
NM_198053 |
| Classification: |
CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000034593 |
| Locus Specific Databases: |
CD247base: Mutation registry for Autosomal recessive CD3Zeta deficiency LRG_36 |