| Also known as: |
TROPONIN I |
| Other names: |
Cardiac troponin I, Troponin I, cardiac muscle, cardiac muscle, cardiac muscle, troponin I, troponin I type 3 (cardiac), troponin I |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CMD1FF, CMD2A, CMH7, RCM1, TNNC1, TNNC1, TNNI3, cTnI, TNNI3 |
| Gene name synonims: |
CMD1FF, CMD2A, CMH7, RCM1, TNNC1, TNNC1, TNNI3, cTnI, TNNI3 |
| Other gene names: |
CMD1FF, CMD2A, CMH7, RCM1, TNNC1, TNNC1, TNNI3, cTnI, TNNI3 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2b |
| Clone: |
1G11 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Changes in cTnI phosphorylation have been reported in failing hearts, It does not cross-react with skeletal Troponin I, Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death, One possible form of phosphorylation is by Protein kinase A, Protein kinase A phosphorylation of serine 22 and serine 23 reduces calcium sensitivity of Troponin and leads to an acceleration in relaxation, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This allows cross-bridging to occur and the muscle to contract, This particular antibody might cross react with speacies outside of the listed ones, Troponin I is a 24kDa subunit of Troponin, When calcium binds to Troponin C, _x000D__x000D_Phosphorylation of cTnI results in changes in the activity and function of Troponin, _x000D__x000D_This item recognises free cTnI and cTnI in complex with other Troponin components, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles, a protein found on muscle tissue responsible for muscle contraction, TROPONIN I This item recognises the phosphorylated form of human cardiac Troponin I (cTnI) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
IgG concentration 1 miligram per 1 mililiter |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Western Blot (WB), ELISA (EIA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
TROPONIN I (CARDIAC/PHOSPHORYLATED) |
| Short name: |
MOUSE Anti-HUMAN TROPONIN I (CARDIAC/PHOSPHORYLATED) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens TROPONIN I (CARDIAC/PHOSPHORYLATED) (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |