| Also known as: |
TLR7 |
| Other names: |
N/A, Toll-like receptor 7, toll-like receptor 7, toll-like receptor 7, toll-like receptor 7-like, toll-like receptor 7 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
TLR7 |
| Other gene names: |
N/A, TLR7, TLR7-like, TLR7 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
4F4 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
HIV-1 (human immunodeficiency virus type I) and Sendai, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, TLR7 recognises and interacts with single-stranded RNA (ssRNA) derived from viruses such as influenza, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_TLRs are highly conserved proteins which play a key role in activation of innate immunity, a 121 kDa type I transmembrane protein which belongs to the toll-like receptor (TLR) family, and is predominantly expressed in the spleen, and some siRNAs, and the production of proinflammatory signaling molecules, lung and placenta, resulting in the activation of the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway, through the recognition of distinct molecular patterns expressed by infectious agents, TLR7 This item specifically recognises human TLR7 (toll-like receptor 7) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Western Blot (WB), ELISA (EIA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
TLR7 |
| Short name: |
MOUSE Anti-HUMAN TLR7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens toll-like receptor 7 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, TLR7 and IDBG-44230 and ENSG00000196664 and 51284, TLR7 and IDBG-639302 and ENSBTAG00000022161 and 493686, Tlr7 and IDBG-185532 and ENSMUSG00000044583 and 170743, siRNA binding, this GO :0000139 and this GO lgi membrane and cellular component this GO :0001774 and microglial cell activation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0003725 and double-stranded RNA binding and molecular function this GO :0003727 and single-stranded RNA binding and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005768 and endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0007252 and I-kappaB phosphorylation and biological process this GO :0008144 and drug binding and molecular function this GO :0010008 and endosome membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0032009 and early pha this GO some and cellular component this GO :0032722 and positive regulation of chemokine production and biological process this GO :0032755 and positive regulation of interleukin-6 production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0034154 and toll-like receptor 7 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0035197 and siRNA binding and molecular function this GO :0036020 and endolysosome membrane and cellular component this GO :0042346 and positive regulation of NF-kappaB import into nucleus and biological process this GO :0043235 and receptor complex and cellular component this GO :0045078 and positive regulation of interferon-gamma biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045356 and positive regulation of interferon-alpha biosynthetic process and biological process this GO :0045359 and positive regulation of interferon-beta biosynthetic process and biological process this GO :0045416 and positive regulation of interleukin-8 biosynthetic process and biological process this GO :0050729 and positive regulation of inflammatory response and biological process this GO :0051607 and defense response to virus and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process, this GO :0003725 : double-stranded RNA binding, this GO :0003725 : double-stranded RNA binding and also this GO :0003727 : single-stranded RNA binding and also this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005515 : protein binding and also this GO :0008144 : drug binding and also this GO :0035197 : siRNA binding, this GO :0003727 : single-stranded RNA binding, this GO :0004888 : transmembrane signaling receptor activity, this GO :0005515 : protein binding, this GO :0008144 : drug binding, this GO :0035197 : siRNA binding, toll-like receptor 7 |
| Identity: |
15631 |
| Gene: |
TLR7 |
More about : TLR7 |
| Long gene name: |
toll like receptor 7 |
| Synonyms gene name: |
toll-like receptor 7 |
| Locus: |
Xp22, 2 |
| Discovery year: |
2001-04-27 |
| GenBank acession: |
AF240467 |
| Entrez gene record: |
51284 |
| Pubmed identfication: |
11022119 |
| RefSeq identity: |
NM_016562 |
| Classification: |
Toll like receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000021137 |
| Locus Specific Databases: |
Mental Retardation database |