| Also known as: |
CD8 ALPHA |
| Other names: |
CD8 antigen, Lyt-2, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, T-cell surface glycoprotein Lyt-2, alpha chain, 1 lymphocyte differentiation antigen (AA at 100), T-cell surface glycoprotein CD8 alpha chain isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD8 ALPHA |
| Other gene names: |
BB154331, Cd8a, Ly-2, Ly-35, Ly-B, Lyt-2, Lyt-2, Lyt2, Cd8a |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
53-6, 7 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
CD8 is expressed on T-cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The CD8 alpha chain specifically binds to class I MHC molecules, This antibody has also been used for depletion of CD8a<, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_CD8 functions as a co-receptor with the T-cell receptor and mediates efficient cell to cell interactions within the immune system, _x000D__x000D_The 53-6, and exists either a homodimer composed of two alpha chains, cells, or a heterodimer composed of one alpha and one beta chain, the alpha chain of the CD8 antigen, +<, /sup>, 7 antibody has been reported to block antigen presentation via MHC class I and inhibit T cell responses to IL-2, CD8 ALPHA This item detects mouse CD8a, sup> |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
IgG concentration 500ug/1000ul |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistology - Frozen (IHC) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Description: |
This transmembrane glycoprotein is detected by monoclonals and has a lot of clones available with different affinity, Cytotoxic T cells cluster differentiators for flow cytometry |
| Gene target: |
CD8 ALPHA |
| Short name: |
RAT ANTI MOUSE CD8 ALPHA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE CD8 a (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1706 |
| Gene: |
CD8A |
More about : CD8A |
| Long gene name: |
CD8a molecule |
| Synonyms gene: |
CD8 |
| Synonyms gene name: |
CD8 antigen, alpha polypeptide (p32) T-cell surface glycoprotein CD8 alpha chain |
| Locus: |
2p11, 2 |
| Discovery year: |
1986-01-01 |
| Entrez gene record: |
925 |
| Pubmed identfication: |
1541829 |
| RefSeq identity: |
NM_001768 |
| Classification: |
CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000130265 |
| Locus Specific Databases: |
CD8Abase: Mutation registry for CD8 deficiency LRG_44 |