| Also known as: |
BUB1 |
| Other names: |
BUB1 budding uninhibited by benzimidazoles 1 homolog, BUB1 mitotic checkpoint serine/threonine kinase, BUB1A, Mitotic checkpoint serine/threonine-protein kinase BUB1, budding uninhibited by benzimidazoles 1 homolog, mitotic checkpoint serine/threonine-protein kinase BUB1, mitotic spindle checkpoint kinase, putative serine/threonine-protein kinase, mitotic checkpoint serine/threonine-protein kinase BUB1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
BUB1 |
| Other gene names: |
BUB1, BUB1A, BUB1L, BUB1L, hBUB1, hBUB1, BUB1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
14H5 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Bub1 co-operates with Aurora B kinase to inhibit Cdc20-mediated activation of the anaphase promoting complex/cyclosome (APC/C) until all the chromosomes correctly align on the microtubule spindle apparatus via their kinetochores, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Bub1 is also required for assembly of a functional inner centromere, _x000D__x000D_Mutation or aberrant Bub1 expression is associated with chromosomal instability, a protein kinase involved in spindle checkpoint function during mitosis, and human cancer, and metaphase congression, aneuploidy, sister chromatid cohesion via targeting of the Shugoshin protein, thus ensuring high fidelity mitotic chromosome segregation, BUB1 This item detects Bub1 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
BUB1 |
| Short name: |
MOUSE Anti-HUMAN BUB1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens budding uninhibited by benzimidazoles 1 homolog (yeast) (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BUB1 and IDBG-628990 and ENSBTAG00000021181 and 514777, BUB1 and IDBG-65670 and ENSG00000169679 and 699, BUB1A and BUB1L and hBUB1, Bub1 and IDBG-205152 and ENSMUSG00000027379 and 12235, centromeric region and cellular component this GO :0000776 and kinetochore and cellular component this GO :0000777 and condensed chromosome kinetochore and cellular component this GO :0000780 and condensed nuclear chromosome, centromeric region and cellular component this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007059 and chromosome segregation and biological process this GO :0007063 and regulation of sister chromatid cohesion and biological process this GO :0007067 and mitotic nuclear division and biological process this GO :0007093 and mitotic cell cycle checkpoint and biological process this GO :0007094 and mitotic spindle assembly checkpoint and biological process this GO :0008283 and cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016772 and transferase activity, nuclei, this GO :0000278 and mitotic cell cycle and biological process this GO :0000775 and chromosome, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0051983 and regulation of chromosome segregation and biological process this GO :0071173 and spindle assembly checkpoint and biological process this GO :0071174 and mitotic spindle checkpoint and biological process this GO :2001244 and positive regulation of intrinsic apoptotic signaling pathway and biological process, budding uninhibited by benzimidazoles 1 homolog (yeast) |
| Identity: |
1148 |
| Gene: |
BUB1 |
More about : BUB1 |
| Long gene name: |
BUB1 mitotic checkpoint serine/threonine kinase |
| Synonyms gene: |
BUB1L |
| Synonyms gene name: |
budding uninhibited by benzimidazoles 1 (yeast homolog) budding uninhibited by benzimidazoles 1 homolog (yeast) |
| Synonyms: |
hBUB1 BUB1A |
| Locus: |
2q13 |
| Discovery year: |
1997-08-18 |
| GenBank acession: |
AF046078 |
| Entrez gene record: |
699 |
| RefSeq identity: |
NM_004336 |
| Havana BLAST/BLAT: |
OTTHUMG00000153638 |