| Also known as: |
TYROSINASE RELATED PROTEIN 1 |
| Other names: |
5, 5, Catalase B, DHICA oxidase, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, catalase B, glycoprotein 75, melanoma antigen gp75, tyrosinase-related protein 1, 5, 6-dihydroxyindole-2-carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CAS2, CAS2, CATB, DHICA oxidase, GP75, OCA3, TRP, TRP, TRP-1, TRP1, TRP1, TYRP, TYRP, TYRP1, TYRRP, b-PROTEIN, TYRP1 |
| Gene name synonims: |
CAS2, CAS2, CATB, DHICA oxidase, GP75, OCA3, TRP, TRP, TRP-1, TRP1, TRP1, TYRP, TYRP, TYRP1, TYRRP, b-PROTEIN, TYRP1 |
| Other gene names: |
CAS2, CAS2, CATB, DHICA oxidase, GP75, OCA3, TRP, TRP, TRP-1, TRP1, TRP1, TYRP, TYRP, TYRP1, TYRRP, b-PROTEIN, TYRP1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
Ta99 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
, Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, TRP-1 is also involved in maintanence of melanosome ultrastructure and affects melanocyte proliferation and cell death, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Defects in TRP-1 affect pigmentation in melanosomes, a 75kDa melanocyte-specific gene product involved in eumelanin synthesis which is present on the melanosomal membrane of melanoma, and have been shown to cause two diseases dependent on skin colour, normal melanocytes and nevi, rufous oculocutaneous albinism (ROCA) occurs predominantly in southern African blacks and oculocutaneous albinism type III (OCA-III/3) a form of albinism with only moderate reduction of pigment, TYROSINASE RELATED PROTEIN 1 This item detects Tyrosinase-related protein-1 (TRP-1) |
| Form/Appearance: |
Concentrate (Concentrated Tissue Culture Supernatant - liquid) |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunohistology - Frozen (IHC) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
TYROSINASE RELATED PROTEIN 1 |
| Short name: |
MOUSE Anti-HUMAN TYROSINASE RELATED PROTEIN 1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens TYROSINASE RELATED PROTEIN 1 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
12450 |
| Gene: |
TYRP1 |
More about : TYRP1 |
| Long gene name: |
tyrosinase related protein 1 |
| Synonyms gene: |
TYRP CAS2 |
| Synonyms: |
GP75 CATB TRP b-PROTEIN OCA3 |
| Locus: |
9p23 |
| Discovery year: |
1991-09-04 |
| GenBank acession: |
L33830 |
| Entrez gene record: |
7306 |
| Pubmed identfication: |
9434945 |
| RefSeq identity: |
NM_000550 |
| Havana BLAST/BLAT: |
OTTHUMG00000021034 |
| Locus Specific Databases: |
Mutations of the Tyrosinase-related Protein 1 Gene Albinism Database |