| Also known as: |
EBP50 |
| Other names: |
EBP50, Ezrin-radixin-moesin-binding phosphoprotein 50, Na(+)/H(+) exchange regulatory cofactor NHE-RF1, Na(+)/H(+) exchange regulatory cofactor NHE-RF1, Na(+)/H(+) exchange regulatory cofactor NHE-RF1, Na+/H+ exchange regulatory co-factor, Regulatory cofactor of Na(+)/H(+) exchanger, Sodium-hydrogen exchanger regulatory factor 1, Solute carrier family 9 isoform A3 regulatory factor 1, cation proton antiporter 3), ezrin-radixin-moesin binding phosphoprotein-50, ezrin-radixin-moesin-binding phosphoprotein 50, isoform 3 regulatory factor 1, member 3 regulator 1, regulatory cofactor of Na(+)/H(+) exchanger, solute carrier family 9, solute carrier family 9 (sodium/hydrogen exchanger), solute carrier family 9 isoform A3 regulatory factor 1, subfamily A (NHE3, Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
EBP50 |
| Other gene names: |
EBP50, EBP50, NHERF, NHERF, NHERF-1, NHERF-1, NHERF1, NHERF1, NPHLOP2, SLC9A3R1, SLC9A3R1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2b |
| Clone: |
EBP-10 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
EBP50 is a PDZ-containing cytoplasmic adaptor molecule, Immunofluorescence studies have revealed the co-localization of EBP50 with actin and ezrin, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have revealed that EBP50 is an important ERM binding partner, This particular antibody might cross react with speacies outside of the listed ones, _x000D_Other ligands which bind to the PDZ domains of EBP50, _x000D_The ERM family of membrane-cytoskeletal linking proteins act to maintain a regulated linkage between actin filaments (F-actin) and the plasma membrane, cystic fibrosis transmembrane conductance regulator and the type II Na/Pi cotransporter Npt2, implicating EBP50 in a diverse range of biological systems, in T cells, in the apical mircovilli of epithelial cells and this role as binding partner has been further shown through the interaction of EBP50 with the transmembrane adaptor protein known as Protein Associated with Glycosphingolipid-enriched microdomains (PAG), include beta-catenin, liver and kidney, namely small intestine, placenta, shown to be expressed in tissues containing polarized epithelia, via its C-terminal domain, which interacts with the N-terminal FERM (four point one ERM) domain of ERM proteins, EBP50 This item specifically recognizes ezrin/radixin/moesin (ERM)-binding phosphoprotein of 50kDa (EBP50) otherwise known as Na+/H+ exchanger regulatory factor (NHERF) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunoprecipitation (IP), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
EBP50 |
| Short name: |
MOUSE Anti-HUMAN EBP50 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens EBP50 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
11075 |
| Gene: |
SLC9A3R1 |
More about : SLC9A3R1 |
| Long gene name: |
SLC9A3 regulator 1 |
| Synonyms gene name: |
cation proton antiporter 3), isoform 3 regulator 1 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 , member 3 regulator 1 solute carrier family 9, solute carrier family 9 (sodium/hydrogen exchanger), subfamily A (NHE3 |
| Synonyms: |
NHERF EBP50 |
| Locus: |
17q25, 1 |
| Discovery year: |
1999-02-26 |
| GenBank acession: |
AF015926 |
| Entrez gene record: |
9368 |
| Pubmed identfication: |
9314537 9430655 |
| Classification: |
PDZ domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000178863 |