| Also known as: |
CD357 |
| Other names: |
Glucocorticoid-induced TNFR-related protein, Tumor necrosis factor receptor superfamily member 18, glucocorticoid-induced TNFR-related protein, member 18, tumor necrosis factor receptor superfamily, tumor necrosis factor receptor superfamily member 18, tumor necrosis factor receptor superfamily member 18 isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD357 |
| Other gene names: |
AITR, Gitr, Gitr, Tnfrsf18, Tnfrsf18 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2b |
| Clone: |
YGITR765 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
CD357 signalling can also enhance the proliferation of naï, Mouse CD357 is predominantly expressed by CD4+/CD25+ T regulatory cells and on CD4+/CD25- cells upon activation, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies demonstrate that mouse GITR ligand (mGITRL) can bind to CD357 and neutralise the suppressive effects of CD4+CD25+ regulatory T cells, This particular antibody might cross react with speacies outside of the listed ones, a member of the tumour necrosis superfamily, also known as glucocorticoid-induced tumour necrosis factor receptor (mGITR) or Tnrfsf18, suggesting a key role for CD357 in the regulation of T cell-mediated immunity, CD357 This product recognises mouse CD357, ve and primed T cells |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD357 |
| Short name: |
RAT ANTI MOUSE CD357 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE CD357 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11914 |
| Gene: |
TNFRSF18 |
More about : TNFRSF18 |
| Long gene name: |
TNF receptor superfamily member 18 |
| Synonyms gene name: |
member 18 , tumor necrosis factor receptor superfamily |
| Synonyms: |
AITR GITR CD357 |
| Locus: |
1p36, 33 |
| Discovery year: |
1998-12-04 |
| GenBank acession: |
AF125304 |
| Entrez gene record: |
8784 |
| Pubmed identfication: |
9177197 10037686 |
| RefSeq identity: |
NM_004195 |
| Classification: |
CD molecules Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000001414 |