| Also known as: |
NOTCH 1 |
| Other names: |
Motch A, Motch A, Neurogenic locus notch homolog protein 1, Notch gene homolog 1, mT14, mT14, major type A protein, neurogenic locus notch homolog protein 1, notch 1, p300, p300, transmembrane receptor Notch1, neurogenic locus notch homolog protein 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
NOTCH 1 |
| Other gene names: |
9930111A19Rik, Mis6, Motch, N1, NICD, Notch 1, Notch1, Tan1, lin-12, Notch1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
mN1A |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
DLL3 and DLL4, Delta like-1 (DLL1), Jagged1 (CD339), Jagged2, Notch 1 signalling plays a role in follicular differentiation, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have also implicated Notch 1 in the regulation of lymphopoeisis, Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_Notch 1 is expressed in a range of cells including haematopoietic cells in mouse foetal liver, _x000D__x000D_The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, adult thymus and bone marrow, and both tumour progression and suppression, and in both CD4+ and CD8+ cell maturation in the thymus, and neurogenesis, cardiac and endocrine development, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, myelopoiesis, on physically adjacent signal receiving cells, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway), releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell haematopoiesis, thymic T-cell development, tissue homeostasis, which is activated through binding to DSL domain-containing membrane-bound specific ligands, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, NOTCH 1 This item specifically recognises Notch 1, _x000D__x000D__x000D_ |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunohistology - Frozen (IHC), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
NOTCH 1 |
| Short name: |
MOUSE Anti-MOUSE NOTCH 1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MOUSE antibody to-MOUSE NOTCH 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7881 |
| Gene: |
NOTCH1 |
More about : NOTCH1 |
| Long gene name: |
notch 1 |
| Synonyms gene: |
TAN1 |
| Synonyms gene name: |
Notch (Drosophila) homolog 1 (translocation-associated) Notch homolog 1, translocation-associated (Drosophila) |
| Locus: |
9q34, 3 |
| Discovery year: |
1992-02-13 |
| GenBank acession: |
AF308602 |
| Entrez gene record: |
4851 |
| Pubmed identfication: |
1831692 |
| RefSeq identity: |
NM_017617 |
| Classification: |
Ankyrin repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000020935 |