| known also as: |
Anti-GOAT ANTI HUMAN NOTCH 3 (C-TERMINAL) |
| known also as: |
Caprine ANTI HUMAN NOTCH 3 (C-TERMINAL) |
| known also as: |
Caprinae ANTI Homo sapiens NOTCH 3 (C-TERMINAL) |
| known also as: |
NOTCH 3 |
| Other names: |
N/A, Neurogenic locus notch homolog protein 3, Notch homolog 3, neurogenic locus notch homolog protein 3, notch 3, neurogenic locus notch homolog protein 3 |
| Gene name: |
NOTCH 3 |
| Other gene names: |
CADASIL, CASIL, NOTCH3, Notch 3, NOTCH3 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
DLL3 and DLL4, Delta-like protein 1 (DLL1), Jagged1 (CD339), Jagged2, Notch 3 is also present on some thymocytes subsets and Treg cells, Studies have implicated the over-expression of Notch 3 in T-cell leukaemia, Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, _x000D__x000D_In humans, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_Notch 3 is primarily expressed by proliferating neuroepithelium and arterial smooth muscle cells, _x000D__x000D_The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, and Notch 3 signalling plays a role in mammalian T cell lineage commitment, and both tumour progression and suppression, and may play a role during CNS development, and stem cell haematopoiesis, cardiac and endocrine development, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, mutations in the Notch3 gene are responsible for the heritable vascular dementia known as CADASIL (cerebral autosomal dominant arteriopathy w, on physically adjacent signal receiving cells, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway), releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell haematopoiesis, thymic T-cell development, thymocyte development, which is activated through binding to DSL domain-containing membrane-bound specific ligands, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, NOTCH 3 This item specifically recognises Notch 3 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
IgG concentration 500ug/1000ul |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 12 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
ELISA (EIA), Immunohistology - Paraffin (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
NOTCH 3 |
| Short name: |
GOAT ANTI HUMAN NOTCH 3 (C-TERMINAL) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens NOTCH 3 (C-TERMINAL) (Antibody to), caprine antibody to H |
| Alternative technique: |
antibodies |
| Identity: |
7883 |
| Gene: |
NOTCH3 |
More about : NOTCH3 |
| Long gene name: |
notch 3 |
| Synonyms gene: |
CADASIL |
| Synonyms gene name: |
Notch (Drosophila) homolog 3 Notch homolog 3 (Drosophila) |
| Synonyms: |
CASIL |
| Locus: |
19p13, 12 |
| Discovery year: |
1994-07-04 |
| GenBank acession: |
U97669 |
| Entrez gene record: |
4854 |
| Pubmed identfication: |
7835890 |
| RefSeq identity: |
NM_000435 |
| Classification: |
Ankyrin repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000183217 |
| Locus Specific Databases: |
NOTCH3 - CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical LOVD - Leiden Open Variation Database |