| Also known as: |
CD123 |
| Other names: |
IL-3 receptor alpha SP2 isoform, IL-3 receptor alpha chain, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, Il-3 alpha subunit, Interleukin-3 receptor class II alpha chain, Interleukin-3 receptor subunit alpha, alpha chain, interleukin 3 receptor, interleukin-3 receptor class II alpha chain, interleukin-3 receptor subunit alpha, interleukin-3 receptor subunit alpha |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD123 |
| Other gene names: |
CD123, CDw123, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, Il3ra, SUT-1, Sut-1, Il3ra |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
5B11 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
AKR/J and NZB/B1NJ are reported to have low levels of CD123 expression due to aberrant splicing of the IL-3R alpha subunit gene, Binding of IL-3 to the IL-3 receptor complex induces the proliferation and differentiation of haematopoietic cells, CD123 can associate with either the common beta subunit CDw131 or with the murine IL-3 beta subunit to form a high affinity receptor for IL-3, CD123 is expressed on haematopoietic progenitors and most myeloid cells including basophils and mast cells, Certain mouse strains including A/J, IL-3 can bind to CD123 itself but with low affinity, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Clone 5B11 does not block the binding of IL-3 to the high affinity IL-3 receptor, _x000D__x000D_In mouse, which is the 70kD alpha chain of the interleukin-3 receptor (IL-3R), CD123 This item recognises murine CD123 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunofluorescence (IF), Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD123 |
| Short name: |
RAT ANTI MOUSE CD123 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE CD123 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6012 |
| Gene: |
IL3RA |
More about : IL3RA |
| Long gene name: |
interleukin 3 receptor subunit alpha |
| Synonyms gene name: |
alpha (low affinity) , interleukin 3 receptor |
| Synonyms: |
CD123 |
| Locus: |
Xp22, 3 , 3 and Yp13 |
| Discovery year: |
1992-10-28 |
| GenBank acession: |
M74782 |
| Entrez gene record: |
3563 |
| Pubmed identfication: |
1833064 |
| Classification: |
CD molecules Pseudoautosomal region 1 Interleukin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000021059 |