| Also known as: |
CD221 |
| Other names: |
IGF-I receptor, Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor, insulin-like growth factor 1 receptor, insulin-like growth factor 1 receptor, insulin-like growth factor I receptor, soluble IGF1R variant 1, soluble IGF1R variant 2, insulin-like growth factor 1 receptor |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD221 |
| Other gene names: |
CD221, IGF-I receptor, IGF1R, IGFIR, IGFR, JTK13, IGF1R |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
1H7 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits, Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221, Clone 1H7 recognises an epitope in the alpha subunits of CD221, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The ligands for CD221 include IGF-I and IGF-II, This particular antibody might cross react with speacies outside of the listed ones, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor), brain, demonstrated by Western blotting CD221 is expressed in a range of tissues, including kidney, liver, mammary gland, ovary and skin, placenta, resulting in phosphorylation of several intracellular signalling proteins, which bind to CD221 and activate tyrosine kinase activity, CD221 This item recognises human CD221 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunohistology - Paraffin (IHC), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD221 |
| Short name: |
MOUSE Anti-HUMAN CD221 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD221 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
5465 |
| Gene: |
IGF1R |
More about : IGF1R |
| Long gene name: |
insulin like growth factor 1 receptor |
| Synonyms gene name: |
insulin-like growth factor 1 receptor |
| Synonyms: |
JTK13 CD221 IGFIR MGC18216 IGFR |
| Locus: |
15q26, 3 |
| Discovery year: |
1988-07-07 |
| GenBank acession: |
M69229 |
| Entrez gene record: |
3480 |
| Pubmed identfication: |
1316909 |
| RefSeq identity: |
NM_000875 |
| Classification: |
CD molecules Fibronectin type III domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000149851 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_1055 |