| known also as: |
Anti-RABBIT ANTI SIGIRR (C-TERMINAL) |
| known also as: |
RABBIT ANTI SIGIRR (C-TERMINAL) |
| known also as: |
Lapin ANTI SIGIRR (C-TERMINAL) |
| known also as: |
SIGIRR |
| Other names: |
Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, single Ig IL-1-related receptor, single Ig IL-1R-related molecule, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, single immunoglobulin domain IL1R1 related, single immunoglobulin domain-containing IL1R-related protein, toll/interleukin-1 receptor 8, single Ig IL-1-related receptor |
| Gene name: |
SIGIRR |
| Other gene names: |
SIGIRR, TIR8, TIR8, SIGIRR |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Mouse |
| Specificity and cross-reactivity: |
It interacts with TLR4, It is not expressed in brain and muscle, SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signalling pathways, SIGIRR is expressed in kidney, TLR5, TLR9 and IL-1R through the extracellular Ig domain, The Ig domain interferes with the heterodimerisation of IL-1R while the intracellular TIR domain inhibits both IL-1 and LPS signalling by attenuating the recruitment of receptor-proximal signalling components to TLR4, a member of the Toll-like receptor-interleukin 1 receptor superfamily, colon, defined by an intracellular Toll-IL-1R (TIR) domain, lung, or the intracellular TIR domain, small intestine, spleen and liver, SIGIRR This item recognises the Single Ig IL-1-related receptor (SIGIRR) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunohistology - Frozen (IHC), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
SIGIRR |
| Short name: |
Anti-SIGIRR (C-TERMINAL) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (C-TERMINAL) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, SIGIRR and IDBG-16551 and ENSG00000185187 and 59307, SIGIRR and IDBG-645604 and ENSBTAG00000011149 and 531801, Sigirr and IDBG-211977 and ENSMUSG00000025494 and 24058, protein binding, this GO :0001960 and negative regulation of cytokine-mediated signaling pathway and biological process this GO :0005515 and protein binding and molecular function this GO :0006953 and acute-phase response and biological process this GO :0007165 and signal transduction and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0031665 and negative regulation of lipopolysaccharide-mediated signaling pathway and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0045079 and negative regulation of chemokine biosynthetic process and biological process this GO :0045087 and innate immune response and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| Identity: |
30575 |
| Gene: |
SIGIRR |
More about : SIGIRR |
| Long gene name: |
single Ig and TIR domain containing |
| Synonyms gene name: |
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| Synonyms: |
TIR8 IL-1R8 |
| Synonyms name: |
single immunoglobulin domain IL1R1 related |
| Locus: |
11p15, 5 |
| Discovery year: |
2005-10-10 |
| Entrez gene record: |
59307 |
| Pubmed identfication: |
10346978 |
| RefSeq identity: |
NM_021805 |
| Classification: |
Immunoglobulin like domain containing TIR domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000165412 |