| known also as: |
Anti-RABBIT ANTI BAK (N-TERMINAL) |
| known also as: |
RABBIT ANTI BAK (N-TERMINAL) |
| known also as: |
Lapin ANTI BAK (N-TERMINAL) |
| known also as: |
BAK |
| Other names: |
Apoptosis regulator BAK, BCL2-antagonist/killer 1, Bcl-2 homologous antagonist/killer, Bcl2 homologous antagonist/killer, apoptosis regulator BAK, bcl-2 homologous antagonist/killer, Bcl-2 homologous antagonist/killer |
| Gene name: |
BAK |
| Other gene names: |
Bak, Bak, Bak1, N-BAK1, N-Bak, Bak1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Bak (and Bax) permeabilises the outer membrane of the mitochondria or the ER to release proapoptogenic factors such as cytochrome c, Bak is a pro-apoptotic Bcl-2 family member similar to Bax with which it is thought to share significant homology, Mcl-1 and Bcl-xL interact with Bak and prevent the activation of Bak in healthy cells, Mcl-1- and Bcl-xL-binding proteins (such as Noxa and Bad) displace Bak and apoptosis is induced, Upon cytotoxic signalling, When activated, an oligomeric protein localised to the outer mitochondrial membrane and the endoplasmic reticulum of healthy cells, BAK This item recognises the Bcl-2 homologous antagonist/killer (Bak) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunohistology - Frozen (IHC), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
BAK |
| Short name: |
Anti-BAK (N-TERMINAL) |
| Alternative name: |
antibody to-BAK (N-TERMINAL) |
| Identity: |
949 |
| Gene: |
BAK1 |
More about : BAK1 |
| Long gene name: |
BCL2 antagonist/killer 1 |
| Synonyms gene: |
CDN1 |
| Synonyms gene name: |
BCL2-antagonist/killer 1 |
| Synonyms: |
BCL2L7 BAK |
| Locus: |
6p21, 31 |
| Discovery year: |
1997-10-09 |
| GenBank acession: |
U23765 |
| Entrez gene record: |
578 |
| Pubmed identfication: |
7715730 7715731 |
| RefSeq identity: |
NM_001188 |
| Classification: |
BCL2 family |
| Havana BLAST/BLAT: |
OTTHUMG00000014530 |