| known also as: |
Anti-RABBIT ANTI HUMAN IRAK4 (C-TERMINAL) |
| known also as: |
RABBIT ANTI HUMAN IRAK4 (C-TERMINAL) |
| known also as: |
Lapin ANTI Homo sapiens IRAK4 (C-TERMINAL) |
| known also as: |
IRAK4 |
| Other names: |
Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64, interleukin-1 receptor-associated kinase 4, interleukin-1 receptor-associated kinase 4, renal carcinoma antigen NY-REN-64, interleukin-1 receptor-associated kinase 4 isoform a |
| Gene name: |
IRAK4 |
| Other gene names: |
IPD1, IRAK-4, IRAK-4, IRAK4, NY-REN-64, REN64, IRAK4 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
IRAK4 functions in this signal transduction pathway by binding to the IL-1 type I receptor following IL-1 engagement, IRAK4 has a molecular weight of 50kD, It is expressed by the liver, _x000D__x000D_IRAK4 is a key activator of TLR-mediated signal transductions and has crucial roles in innate immune responses, and is an important mediator in the signal transduction of Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family members, kidneys and skeletal muscle, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilization, IRAK4 This item detects an epitope within the C-terminal (CT) region of integrin-1 receptor-associated kinase 4 (IRAK4) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunohistology - Frozen (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
IRAK4 |
| Short name: |
Anti-HUMAN IRAK4 (C-TERMINAL) |
| Alternative name: |
sapiens interleukin-1 receptor-associated kinase 4 (C-TERMINAL), antibody to-H |
| Alternative to gene target: |
Extracellular, IRAK4 and IDBG-28022 and ENSG00000198001 and 51135, IRAK4 and IDBG-633310 and ENSBTAG00000021105 and 533692, Irak4 and IDBG-177236 and ENSMUSG00000059883 and 266632, this GO :0000287 and magnesium ion binding and molecular function this GO :0001816 and cytokine production and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005149 and interleukin-1 receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007254 and JNK cascade and biological process this GO :0010008 and endosome membrane and cellular component this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005149 : interleukin-1 receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005149 : interleukin-1 receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0045087 and innate immune response and biological process this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process, interleukin-1 receptor-associated kinase 4 |
| Identity: |
17967 |
| Gene: |
IRAK4 |
More about : IRAK4 |
| Long gene name: |
interleukin 1 receptor associated kinase 4 |
| Synonyms: |
NY-REN-64 |
| Locus: |
12q12 |
| Discovery year: |
2002-09-27 |
| GenBank acession: |
AF155118 |
| Entrez gene record: |
51135 |
| Pubmed identfication: |
3772297 10508479 |
| Havana BLAST/BLAT: |
OTTHUMG00000169425 |
| Locus Specific Databases: |
IRAK4base: Mutation registry for IRAK4 deficiency LRG_75 |