| known also as: |
Anti-RABBIT ANTI HUMAN IRAK3 |
| known also as: |
RABBIT ANTI HUMAN IRAK3 |
| known also as: |
Lapin ANTI Homo sapiens IRAK3 |
| known also as: |
IRAK3 |
| Other names: |
IL-1 receptor-associated kinase M, IL-1 receptor-associated kinase M, Interleukin-1 receptor-associated kinase 3, interleukin-1 receptor-associated kinase 3, interleukin-1 receptor-associated kinase 3, interleukin-1 receptor-associated kinase 3 isoform b |
| Gene name: |
IRAK3 |
| Other gene names: |
ASRT5, IRAK-3, IRAK-M, IRAK3, IRAKM, IRAK3 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Defects in the IRAK3 gene are associated with susceptibility to asthma-related traits type 5, IRAKs associate with the IL1/Toll receptors after IL-1 or LPS stimulation, It is predominantly expressed in peripheral blood lymphocytes, _x000D__x000D_IRAK3 inhibits the dissociation of IRAK1 and IRAK4 from the Toll-like receptor signalling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilising the receptor complex, _x000D__x000D_This item does not cross-react with IRAK or IRAK2, a member of the IRAK/Pelle family, thereby playing an important role in the inflammatory response, IRAK3 This item recognises human Interleukin-1 receptor-associated kinase 3 (IRAK3) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
5 mg/ml, IgG concentration 0 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunohistology - Paraffin (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
IRAK3 |
| Short name: |
Anti-HUMAN IRAK3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens interleukin-1 receptor-associated kinase 3 (Antibody to), antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ASRT5 and IRAKM, IRAK3 and IDBG-45584 and ENSG00000090376 and 11213, IRAKM and IDBG-634310 and ENSBTAG00000007636 and 510342, Irak3 and IDBG-192499 and ENSMUSG00000020227 and 73914, nuclei, this GO :0000287 and magnesium ion binding and molecular function this GO :0001960 and negative regulation of cytokine-mediated signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0009615 and response to virus and biological process this GO :0010933 and positive regulation of macrophage tolerance induction and biological process this GO :0010936 and negative regulation of macrophage cytokine production and biological process this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity, transferring phosphorus-containing groups and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032494 and response to peptidoglycan and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032695 and negative regulation of interleukin-12 production and biological process this GO :0032715 and negative regulation of interleukin-6 production and biological process this GO :0032720 and negative regulation of tumor necrosis factor production and biological process this GO :0034122 and negative regulation of toll-like receptor signaling pathway and biological process this GO :0042177 and negative regulation of protein catabolic process and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043242 and negative regulation of protein complex disassembly and biological process this GO :0043244 and regulation of protein complex disassembly and biological process this GO :0043330 and response to exogenous dsRNA and biological process this GO :0043407 and negative regulation of MAP kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045824 and negative regulation of innate immune response and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0070498 and interleukin-1-mediated signaling pathway and biological process this GO :0070555 and response to interleukin-1 and biological process, interleukin-1 receptor-associated kinase 3 |
| Identity: |
17020 |
| Gene: |
IRAK3 |
More about : IRAK3 |
| Long gene name: |
interleukin 1 receptor associated kinase 3 |
| Synonyms gene name: |
interleukin-1 receptor-associated kinase 3 |
| Synonyms: |
IRAK-M |
| Locus: |
12q14, 3 |
| Discovery year: |
2002-07-17 |
| GenBank acession: |
AF113136 |
| Entrez gene record: |
11213 |
| Pubmed identfication: |
10383454 |
| Havana BLAST/BLAT: |
OTTHUMG00000169002 |