| Also known as: |
CD178 |
| Other names: |
APTL, Apoptosis antigen ligand, CD95 ligand, CD95 ligand, CD95-L, CD_antigen: CD178Cleaved into the following 4 chains:Tumor necrosis factor ligand superfamily member 6, Fas antigen ligand, Fas ligand, Fas ligand (TNF superfamily, FasL, Soluble Fas ligand, Tumor necrosis factor ligand superfamily member 6, Tumor necrosis factor ligand superfamily member 6, apoptosis (APO-1) antigen ligand 1, apoptosis antigen ligand, fas antigen ligand, member 6, member 6), membrane form, sFasL, soluble formAlternative name(s):Receptor-binding FasL ectodomain, tumor necrosis factor (ligand) superfamily, tumor necrosis factor ligand superfamily member 6, tumor necrosis factor ligand superfamily member 6 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD178 |
| Other gene names: |
ALPS1B, APL, APT1LG1, APT1LG1, APTL, APTL, CD178, CD95-L, CD95-L, CD95L, CD95L, FASL, FASL, FASLG, Fas ligand, FasL, FasL ICD, SPA, TNFSF6, TNFSF6, sFasL, FASLG |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
10F2 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Binding of CD178 to Fas (CD95) results in the induction of apoptosis, CD178 is a member of the TNF family, CD178 plays an important role in T cell development and cytotoxicity, Clone 10F2 is reported to block the activity of Fas ligand, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The protein may exist as either a membrane bound or a cleaved soluble form, This particular antibody might cross react with speacies outside of the listed ones, a 40kDa glycoprotein also known as Fas ligand (CD95L), which is expressed by activated T lymphocytes and NK cells, CD178 This item recognises the human CD178 cell surface antigen |
| Form/Appearance: |
Low Endotoxin (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, only, the antibody should be stored undiluted, Store the antibody should be stored at -20 degrees Celsius |
| Tested applications:: |
ELISA (EIA), Flow Cytometry (FACS), Functional Assay (FA), Immunoprecipitation (IP) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD178: Endotoxin |
| Short name: |
MOUSE Anti-HUMAN CD178:Low Endotoxin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD178:Low Endotoxin (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
11936 |
| Gene: |
FASLG |
More about : FASLG |
| Long gene name: |
Fas ligand |
| Synonyms gene: |
APT1LG1 TNFSF6 |
| Synonyms gene name: |
member 6 Fas ligand (TNF superfamily, member 6) , tumor necrosis factor (ligand) superfamily |
| Synonyms: |
FasL CD178 |
| Locus: |
1q24, 3 |
| Discovery year: |
1994-12-09 |
| GenBank acession: |
U11821 |
| Entrez gene record: |
356 |
| Pubmed identfication: |
7826947 9022072 |
| Classification: |
Endogenous ligands Tumor necrosis factor superfamily CD molecules Death inducing signaling complex |
| Havana BLAST/BLAT: |
OTTHUMG00000034841 |
| Locus Specific Databases: |
FASLGbase: Mutation registry for Autoimmune lymphoproliferative syndrome, type 1B (ALPS1B) (previously known as TNFSF6base) LRG_58 |