| known also as: |
Anti-RABBIT ANTI HRK |
| known also as: |
RABBIT ANTI HRK |
| known also as: |
Lapin ANTI HRK |
| known also as: |
HRK |
| Other names: |
Activator of apoptosis harakiri, BCL2 interacting protein (contains only BH3 domain), BCL2-interacting protein, BH3-interacting domain-containing protein 3, BH3-interacting domain-containing protein 3, Neuronal death protein DP5, activator of apoptosis Hrk, activator of apoptosis harakiri, death protein 5, harakiri, neuronal death protein DP5, activator of apoptosis harakiri |
| Gene name: |
HRK |
| Other gene names: |
BID3, DP5, HARAKIRI, HRK, HRK |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Despite its predicted molecular weight, HRK is a BH3 only protein of the Bcl-2 family, HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, HRK often migrates at 12-15kD, HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, _x000D_Aberrant methylation of HRK is frequently detected in primary colorectal cancers, also known as DP5, and in conjunction to the mitochondrial pore forming protein p32, in particular to growth factor deprivation, which promotes Bax dependent apoptosis, HRK Detects Harakiri (HRK) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
HRK |
| Short name: |
Anti-HRK |
| Alternative name: |
BCL2 interacting protein (contains only BH3 domain), antibody to-harakiri |
| Alternative to gene target: |
BCL2 interacting protein (contains only BH3 domain), DP5 and HARAKIRI, HRK and IDBG-59297 and ENSG00000135116 and 8739, HRK and IDBG-633660 and ENSBTAG00000047484 and 787139, Hrk and IDBG-195140 and ENSMUSG00000046607 and 12123, Plasma membranes, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005739 and mitochondrion and cellular component this GO :0006915 and apoptotic process and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0032464 and positive regulation of protein homooli this GO merization and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, harakiri |
| Identity: |
5185 |
| Gene: |
HRK |
More about : HRK |
| Long gene name: |
BCL2 interacting protein , harakiri |
| Synonyms gene name: |
BCL2-interacting protein (contains only BH3 domain) , harakiri |
| Synonyms: |
DP5 |
| Synonyms name: |
death protein 5 |
| Locus: |
12q24, 22 |
| Discovery year: |
1999-05-21 |
| GenBank acession: |
U76376 |
| Entrez gene record: |
8739 |
| Pubmed identfication: |
9130713 |
| Classification: |
BCL2 homology region 3 (BH3) only |
| Havana BLAST/BLAT: |
OTTHUMG00000169328 |