| known also as: |
Anti-RABBIT ANTI AES (C-TERMINAL) |
| known also as: |
RABBIT ANTI AES (C-TERMINAL) |
| known also as: |
Lapin ANTI AES (C-TERMINAL) |
| known also as: |
AES |
| Other names: |
Amino-terminal enhancer of split, Gp130-associated protein GAM, Protein ESP1, Protein GRG, amino-terminal enhancer of split, amino-terminal enhancer of split, gp130-associated protein GAM, amino-terminal enhancer of split isoform b |
| Gene name: |
AES |
| Other gene names: |
AES, AES-1, AES-2, Amino enhancer of split, ESP1, GRG, GRG, GRG5, TLE5, AES |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Groucho protein, Studies show that this type of apoptosis is controlled by integrin-mediated signaling pathways and that the mitochondrial protein Bit1 (Bcl-2 inhibitor of transcription), The effects of the interaction between Bit1 and AES can be counteracted by the attachment of cells to fibronectin through integrin a5beta1, _x000D__x000D_The detachment of integrin from the extracellular matrix (ECM), a member of the Groucho/transducin-like enhancer of split (TLE) family of transcriptional regulators, forms a complex with AES, homologous to the amino-terminal domain of <, released into the cytoplasm during apoptosis, results in loss of cell adhesion and cell death, termed anoikis, to induce cell death, /i>, AES Recognises an epitope within the C-terminal region (CT) of the 197-amino acid protein AES (amino-terminal enhancer of split), Drosophila<, _x000D_, i> |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
AES |
| Short name: |
Anti-AES (C-TERMINAL) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-amino-terminal enhancer on split (C-TERMINAL) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AES and IDBG-16753 and ENSG00000104964 and 166, AES and IDBG-644452 and ENSBTAG00000031363 and 505375, AES-1 and AES-2 and ESP1 and GRG and GRG5 and TLE5, Aes and IDBG-178824 and ENSMUSG00000054452 and 14797, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016055 and Wnt signaling pathway and biological process this GO :0031668 and cellular response to extracellular stimulus and biological process this GO :0032091 and negative regulation of protein binding and biological process this GO :0040008 and regulation of growth and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0060761 and negative regulation of response to cytokine stimulus and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0090090 and negative regulation of canonical Wnt signaling pathway and biological process this GO :2000210 and positive regulation of anoikis and biological process, nuclei, protein binding, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001501 and skeletal system development and biological process this GO :0003714 and transcription corepressor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006351 and transcription, this GO :0003714 : transcription corepressor activity, this GO :0003714 : transcription corepressor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, amino-terminal enhancer of split |
| Identity: |
307 |
| Gene: |
AES |
More about : AES |
| Long gene name: |
amino-terminal enhancer of split |
| Synonyms: |
GRG5 TLE5 |
| Locus: |
19p13, 3 |
| Discovery year: |
1993-12-13 |
| GenBank acession: |
AK094591 |
| Entrez gene record: |
166 |
| Pubmed identfication: |
8365415 |
| RefSeq identity: |
NM_198969 |
| Havana BLAST/BLAT: |
OTTHUMG00000180567 |