| known also as: |
Anti-RABBIT ANTI 5-LIPOXYGENASE (pSer523) |
| known also as: |
RABBIT ANTI 5-LIPOXYGENASE (pSer523) |
| known also as: |
Lapin ANTI 5-LIPOXYGENASE (pSer523) |
| known also as: |
5-LIPOXYGENASE |
| Other names: |
Arachidonate 5-lipoxygenase, LOX-5, N/A, arachidonate 5-lipoxygenase, arachidonate 5-lipoxygenase, arachidonic 5-lipoxygenase alpha-10 isoform, arachidonic 5-lipoxygenase delta-10-13 isoform, arachidonic 5-lipoxygenase delta-13 isoform, arachidonic 5-lipoxygenase delta-p10 isoform, arachidonic acid 5-lipoxygenase, leukotriene A4 synthase, arachidonate 5-lipoxygenase isoform 1 |
| Gene name: |
5-LIPOXYGENASE |
| Other gene names: |
5-LO, 5-LO, 5-LOX, 5LPG, ALOX5, LOG5, LOG5, ALOX5 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
5-LO is an enzyme that catalyses the synthesis of leukotrienes (LT's) from arachidonic acid (a polyunsaturated fatty acid), 5-LO requires calcium, ATP and the 5-LO-activating protein as cofactors for full activity, I recent years 5-LO has also been implicated in the regulation of cell proliferation and apoptosis and has been found in a broad variety of cancer cells, Leukotrienes are synthesised and secreted by leukocytes in response to immunologic or inflammatory stimuli, The biological effects of LT's include leukocyte chemotaxis, also known as arachidonate 5-lipoxygenase) when phosphorylated at Ser523, by the insertion of an oxygen into the arachidonic backbone, mucous hypersecretion, pulmonary airway constriction, such as in asthma and allergic reactions, vasoconstriction and increased vascular permeability, 5-LIPOXYGENASE This item specifically recognises human 5-lipoxygenase (5-LO |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
5-LIPOXYGENASE (pSer523) |
| Short name: |
Anti-5-LIPOXYGENASE (pSer523) |
| Alternative name: |
antibody to-5-LIPOXYGENASE (pSer523) |