| known also as: |
Anti-RABBIT ANTI HUMAN PDCD4 (C-TERMINAL) |
| known also as: |
RABBIT ANTI HUMAN PDCD4 (C-TERMINAL) |
| known also as: |
Lapin ANTI Homo sapiens PDCD4 (C-TERMINAL) |
| known also as: |
PDCD4 |
| Other names: |
Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Programmed cell death protein 4, Protein 197/15a, neoplastic transformation inhibitor protein, nuclear antigen H731, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death protein 4, protein 197/15a, programmed cell death protein 4 isoform 1 |
| Gene name: |
PDCD4 |
| Other gene names: |
H731, H731, PDCD4, PDCD4 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Pdcd4 expression is down regulated with tumour progression in carcinomas of the lung, Pdcd4 has also been shown to inhibit transcription factor activator protein-1 (AP-1), Pdcd4 interacts with the RNA helicase eIF4A and the scaffolding protein eIF4G, _x000D__x000D_Pdcd4 localizes to the nucleus in proliferating cells, a novel tumour suppressor, and its expression is modulated by cytokines in natural killer and T cells, and thus inhibits protein synthesis, colon, including expression of matrix metalloproteinases and cell motility, prostate and breast, two components of the translation initiation complex, which regulates several events required for cell invasion, PDCD4 This item detects a specific epitope within the carboxy-terminal of programmed cell death 4 (Pdcd4) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunohistology - Paraffin (IHC), Western Blot (WB), ELISA (EIA) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
PDCD4 |
| Short name: |
Anti-HUMAN PDCD4 (C-TERMINAL) |
| Alternative name: |
sapiens programmed cellular death 4 (neoplastic transformation inhibitor) (C-TERMINAL), antibody to-H |
| Alternative to gene target: |
DNA-templated and biological process, PDCD4 and IDBG-639738 and ENSBTAG00000019434 and 506724, PDCD4 and IDBG-89535 and ENSG00000150593 and 100616113, Pdcd4 and IDBG-176913 and ENSMUSG00000024975 and 18569, nuclei, protein binding, this GO :0003723 and RNA binding and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007569 and cell aging and biological process this GO :0043508 and negative regulation of JUN kinase activity and biological process this GO :0045786 and negative regulation of cell cycle and biological process this GO :0045892 and negative regulation of transcription, this GO :0003723 : RNA binding, this GO :0003723 : RNA binding and also this GO :0005488 : binding and also this GO :0005515 : protein binding, this GO :0005488 : binding, this GO :0005515 : protein binding, 27250, programmed cell death 4 (neoplastic transformation inhibitor) |
| Identity: |
8763 |
| Gene: |
PDCD4 |
More about : PDCD4 |
| Long gene name: |
programmed cell death 4 |
| Synonyms gene name: |
programmed cell death 4 (neoplastic transformation inhibitor) |
| Synonyms: |
H731 |
| Synonyms name: |
nuclear antigen H731 |
| Locus: |
10q25, 2 |
| Discovery year: |
2000-05-10 |
| GenBank acession: |
U83908 |
| Entrez gene record: |
27250 |
| Pubmed identfication: |
9759869 |
| RefSeq identity: |
NM_014456 |
| Havana BLAST/BLAT: |
OTTHUMG00000019048 |