| known also as: |
Anti-RABBIT ANTI HUMAN HER2/neu (pThr686) |
| known also as: |
RABBIT ANTI HUMAN HER2/neu (pThr686) |
| known also as: |
Lapin ANTI Homo sapiens HER2/neu (pThr686) |
| known also as: |
HER2/neu |
| Other names: |
MLN 19, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2, c-erb B2/neu protein, herstatin, metastatic lymph node gene 19 protein, neuro/glioblastoma derived oncogene homolog (avian), neuroblastoma/glioblastoma derived oncogene homolog, p185erbB2, p185erbB2, proto-oncogene Neu, proto-oncogene c-ErbB-2, receptor tyrosine-protein kinase erbB-2, tyrosine kinase-type cell surface receptor HER2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, receptor tyrosine-protein kinase erbB-2 isoform b |
| Gene name: |
HER2/neu |
| Other gene names: |
CD340, ERBB2, HER-2, HER-2/neu, HER2, HER2, MLN 19, MLN 19, MLN19, NEU, NEU, NGL, NGL, TKR1, ERBB2 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Some binding to unphosphorylated HER2/neu may be seen at higher concentrations, _x000D_Excessive HER2/neu is present in around 20% to 25% of invasive breast cancers, _x000D_HER2/neu is a proto-oncogene expressed at the cell surface of a range of tumour cells, and an increased risk of metastasis, and can help determine whether drugs such as trastuzumab (Herceptin) or lapatinib (Tykerb), and is used in conjunction with antibodies recognising both Estrogen and Progesterone receptors, and to determine patient prognosis and course of treatment, but this may be overcome by appropriate titration, for the classification of breast cancer tumours, might be beneficial, otherwise known as CD340 and c-ErbB-2, phosphorylated at threonine residue (amino acid 686), referred to as HER2-positive cancer, which is often associated with poor prognosis, HER2/neu This antibody recognises human HER2/neu, _x000D_ |
| Form/Appearance: |
Serum (Serum - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunohistology - Frozen (IHC), Western Blot (WB), ELISA (EIA) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
HER2/neu (pThr686) |
| Short name: |
Anti-HUMAN HER2/neu (pThr686) |
| Alternative name: |
sapiens HER2/neu (pThr686), antibody to-H |
| Identity: |
3430 |
| Gene: |
ERBB2 |
More about : ERBB2 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 2 |
| Synonyms gene: |
NGL |
| Synonyms gene name: |
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 |
| Synonyms: |
NEU HER-2 CD340 HER2 |
| Synonyms name: |
neuro/glioblastoma derived oncogene homolog human epidermal growth factor receptor 2 |
| Locus: |
17q12 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
X03363 |
| Entrez gene record: |
2064 |
| RefSeq identity: |
NM_004448 |
| Classification: |
CD molecules Minor histocompatibility antigens Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000179300 |
| Locus Specific Databases: |
LRG_724 |