| known also as: |
Anti-RABBIT ANTI MOUSE BLNK |
| known also as: |
RABBIT ANTI Murine BLNK |
| known also as: |
Lapin ANTI Mus musculus BLNK |
| known also as: |
BLNK |
| Other names: |
B cell linker, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, B-cell adapter containing a Src homology 2 domain protein, B-cell linker protein, B-cell linker protein, Cytoplasmic adapter protein, Lymphocyte antigen 57, Src homology 2 domain-containing leukocyte protein of 65 kDa, cytoplasmic adapter protein, lymphocyte antigen 57, src homology 2 domain-containing leukocyte protein of 65 kDa, B-cell linker protein |
| Gene name: |
BLNK |
| Other gene names: |
BASH, Bash, Bca, Blnk, Ly-57, Ly57, Ly57, Lyw-57, SLP-65, Slp-65, Slp65, Blnk |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Mouse |
| Specificity and cross-reactivity: |
PLC gamma and the adaptor proteins Crb2 and Nck, The resulting tyrosine phosphorylation of BLNK by syk, _x000D__x000D_BLNK plays a pivotal role in B cell activation through cross-linkage of the B-cell Receptor (BCR), a cytosolic adaptor molecule, differentiation and apoptosis, leading to the activation of protein tyrosine kinases (PTKs) including syk, provides docking sites for the SH2-containing effector molecules such as Vav, thereby acting as a central linker protein in many different B cell signalling pathways involved in proliferation, visualised as two phosphoproteins of 68 and 70kDa in SDS/PAGE, BLNK This item recognises B-cell Linker Protein (BLNK) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, Ig concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
BLNK |
| Short name: |
Anti-MOUSE BLNK |
| Alternative name: |
antibody to-MOUSE B-cell linker |
| Alternative to gene target: |
BLNK and IDBG-83724 and ENSG00000095585 and 29760, BT, Blnk and IDBG-165316 and ENSMUSG00000061132 and 17060, Plasma membranes, protein binding, this GO :0005068 and transmembrane receptor protein tyrosine kinase adaptor activity and molecular function this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0006959 and humoral immune response and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0030183 and B cell differentiation and biological process this GO :0035556 and intracellular signal transduction and biological process, this GO :0005068 : transmembrane receptor protein tyrosine kinase adaptor activity, this GO :0005068 : transmembrane receptor protein tyrosine kinase adaptor activity and also this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005515 : protein binding, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005515 : protein binding, 24520 and IDBG-638042 and ENSBTAG00000021358 and 510393, B-cell linker |
| Identity: |
14211 |
| Gene: |
BLNK |
More about : BLNK |
| Long gene name: |
B-cell linker |
| Synonyms: |
SLP65 Ly57 SLP-65 BLNK-s BASH bca |
| Synonyms name: |
B-cell adapter containing a SH2 domain protein B-cell activation Src homology [SH2] domain-containing leukocyte protein of 65 kD B cell adaptor containing SH2 domain |
| Locus: |
10q24, 1 |
| Discovery year: |
2001-07-16 |
| GenBank acession: |
AF068180 |
| Entrez gene record: |
29760 |
| Pubmed identfication: |
9697839 10583958 |
| RefSeq identity: |
NM_013314 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000018827 |
| Locus Specific Databases: |
BLNKbase: Mutation registry for BLNK deficiency LRG_21 |