| known also as: |
Anti-RABBIT ANTI AMYLOID PRECURSOR PROTEIN (C-TERMINAL) |
| known also as: |
RABBIT ANTI AMYLOID PRECURSOR PROTEIN (C-TERMINAL) |
| known also as: |
Lapin ANTI AMYLOID PRECURSOR PROTEIN (C-TERMINAL) |
| known also as: |
AMYLOID PRECURSOR PROTEIN |
| Other names: |
ABPP, AICD-50, AICD-57, AICD-59, AID(50), AID(57), AID(59), APP, APPI, Alternative name(s):, Alternative name(s):, Alternative name(s):, Alternative name(s):, Alternative name(s):, Alzheimer disease amyloid protein, Amyloid beta A4 protein, Amyloid intracellular domain 50, Amyloid intracellular domain 57, Amyloid intracellular domain 59, Beta-APP40C83P3(42)P3(40)C80Gamma-secretase C-terminal fragment 59, Beta-APP42Beta-amyloid protein 40, CVAP, Cerebral vascular amyloid peptide, Gamma-CTF(50), Gamma-CTF(57)Gamma-secretase C-terminal fragment 50, Gamma-CTF(59)Gamma-secretase C-terminal fragment 57, PN-IICleaved into the following 14 chains:N-APPSoluble APP-alpha, PreA4, Protease nexin-II, S-APP-alphaSoluble APP-beta, S-APP-betaC99Beta-amyloid protein 42, alzheimer disease amyloid protein, amyloid beta (A4) precursor protein, amyloid beta A4 protein, beta-amyloid peptide, cerebral vascular amyloid peptide, peptidase nexin-II, preA4, protease nexin-II, amyloid beta A4 protein isoform a |
| Other gene names: |
A4, AAA, ABETA, ABPP, AD1, AD1, AICD-50, AICD-57, AICD-59, AID(50), AID(57), AID(59), APP, APP, APPI, CTFgamma, CVAP, CVAP, PN-II, PN-II, PN2, S-APP-alpha, S-APP-beta, APP |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Specificity and cross-reactivity: |
APP also inhibits Notch signaling through it's interaction with NUMB, The C99 fragment itself is a substrate for gamma-secretase to generate the 4kD beta amyloid peptide which is found in the brains of Alzheimer's disease patients, The sequence recognised by this antibody corresponds to amino acids 85-99 of the C99 fragment, and also the C99 fragment generated by Beta-secretase, AMYLOID PRECURSOR PROTEIN This item recognises both intact APP |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
5 mg/ml, IgG concentration 0 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunohistology - Paraffin (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
AMYLOID PRECURSOR PROTEIN |
| Short name: |
Anti-AMYLOID PRECURSOR PROTEIN (C-TERMINAL) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-AMYLOID PRECURSOR PROTEIN (C-TERMINAL) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
620 |
| Gene: |
APP |
More about : APP |
| Long gene name: |
amyloid beta precursor protein |
| Synonyms gene: |
AD1 |
| Synonyms gene name: |
Alzheimer disease amyloid beta (A4) precursor protein |
| Synonyms name: |
peptidase nexin-II |
| Locus: |
21q21, 3 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M15533 |
| Entrez gene record: |
351 |
| Pubmed identfication: |
1679289 |
| RefSeq identity: |
NM_000484 |
| Classification: |
Endogenous ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000078438 |
| Locus Specific Databases: |
Alzheimer Disease &, Frontotemporal Dementia Mutation Database |