| known also as: |
Anti-RABBIT ANTI APAF1 (aa12-28) |
| known also as: |
RABBIT ANTI APAF1 (aa12-28) |
| known also as: |
Lapin ANTI APAF1 (aa12-28) |
| known also as: |
APAF1 |
| Other names: |
Apoptotic protease-activating factor 1, N/A, apoptotic peptidase activating factor 1, apoptotic protease-activating factor 1, apoptotic protease-activating factor 1 isoform b |
| Gene name: |
APAF1 |
| Other gene names: |
APAF-1, APAF-1, APAF1, CED4, KIAA0413, APAF1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Apaf1 binds to cytochrome C and caspase-9 leading to caspase-9 activation, Apaf1 can also associate with caspase-4 and caspase-8, Elegans, This item recognises a 130kD band in Western blots, resulting in the beginning of the proteolytic cascade characteristic of apoptosis, APAF1 Apaf1 (Apoptosis protease activating factor 1) is the mammalian homologue of the CED-4 cell death protein in C |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
5 mg/ml, IgG concentration 0 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunohistology - Paraffin (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
APAF1 (aa12-28) |
| Short name: |
Anti-APAF1 (aa12-28) |
| Alternative name: |
antibody to-apoptotic peptidase activating factor 1 (aa12-28) |
| Alternative to gene target: |
ADP binding, APAF-1 and CED4, APAF1 and IDBG-52364 and ENSG00000120868 and 317, APAF1 and IDBG-636787 and ENSBTAG00000021661 and 537782, Apaf1 and IDBG-185032 and ENSMUSG00000019979 and 11783, nuclei, this GO :0000166 and nucleotide binding and molecular function this GO :0001843 and neural tube closure and biological process this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005829 and cytosol and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006952 and defense response and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007399 and nervous system development and biological process this GO :0007420 and brain development and biological process this GO :0008635 and activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c and biological process this GO :0008656 and cysteine-type endopeptidase activator activity involved in apoptotic process and molecular function this GO :0030900 and forebrain development and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043293 and apoptosome and cellular component this GO :0043531 and ADP binding and molecular function this GO :0051402 and neuron apoptotic process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0072432 and response to G1 DNA damage checkpoint signaling and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :1902510 and regulation of apoptotic DNA fragmentation and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, this GO :0000166 : nucleotide binding, this GO :0000166 : nucleotide binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008656 : cysteine-type endopeptidase activator activity involved in apoptotic process and also this GO :0042802 : identical protein binding and also this GO :0043531 : ADP binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008656 : cysteine-type endopeptidase activator activity involved in apoptotic process, this GO :0042802 : identical protein binding, this GO :0043531 : ADP binding, apoptotic peptidase activating factor 1 |
| Identity: |
576 |
| Gene: |
APAF1 |
More about : APAF1 |
| Long gene name: |
apoptotic peptidase activating factor 1 |
| Synonyms gene name: |
apoptotic protease activating factor apoptotic peptidase activating factor |
| Synonyms: |
CED4 APAF-1 |
| Locus: |
12q23, 1 |
| Discovery year: |
1998-01-20 |
| GenBank acession: |
AF013263 |
| Entrez gene record: |
317 |
| Pubmed identfication: |
9267021 10702682 |
| RefSeq identity: |
NM_181861, 1 |
| Classification: |
Caspase recruitment domain containing Apoptosome WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000170214 |