| known also as: |
Anti-RABBIT ANTI RAF-1 (pSer642) |
| known also as: |
RABBIT ANTI RAF-1 (pSer642) |
| known also as: |
Lapin ANTI RAF-1 (pSer642) |
| known also as: |
RAF-1 |
| Other names: |
C-RAF, Proto-oncogene c-RAF, RAF proto-oncogene serine/threonine-protein kinase, RAF proto-oncogene serine/threonine-protein kinase, Raf-1, cRaf, cRaf, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV), proto-oncogene c-RAF, raf-1, v-raf-1 murine leukemia viral oncogene homolog 1, v-raf-leukemia viral oncogene 1, RAF proto-oncogene serine/threonine-protein kinase |
| Gene name: |
RAF-1 |
| Other gene names: |
N/A, Raf, Raf1, cRaf, Raf1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Rat |
| Specificity and cross-reactivity: |
As such Raf-1 is an important clinical target in cancer, ERK when activated regulates the expression of genes involved in cell cycle, Raf-1 is a MAP kinase kinase kinase and participates in the transduction of mitogenic signals from receptors on the cell membrane to the nucleus, Raf-1 is activated through phosphorylation by Ras and in turn phosphorylates MEK which activates ERK, _x000D__x000D_Raf-1 activity can be downregulated by phosphorylation at serine residues 301 and 642, a ubiquitously expressed 74 kDa member of the serine/threonine protein kinase family, differentiation, migration and apoptosis, RAF-1 This item recognises Raf-1 phosphorylated at serine 642 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 12 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
RAF-1 (pSer642) |
| Short name: |
Anti-RAF-1 (pSer642) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-RAF-1 (pSer642) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9829 |
| Gene: |
RAF1 |
More about : RAF1 |
| Long gene name: |
Raf-1 proto-oncogene, serine/threonine kinase |
| Synonyms gene name: |
v-raf-1 murine leukemia viral oncogene homolog 1 |
| Synonyms: |
Raf-1 c-Raf CRAF |
| Synonyms name: |
C-Raf proto-oncogene, serine/threonine kinase |
| Locus: |
3p25, 2 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
X03484 |
| Entrez gene record: |
5894 |
| Pubmed identfication: |
1611909 |
| RefSeq identity: |
NM_002880 |
| Classification: |
RAF family Mitogen-activated protein kinase kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000129789 |
| Locus Specific Databases: |
LRG_413 |