| known also as: |
Anti-RABBIT ANTI MUNC-18 (pSer515) |
| known also as: |
RABBIT ANTI MUNC-18 (pSer515) |
| known also as: |
Lapin ANTI MUNC-18 (pSer515) |
| known also as: |
MUNC-18 |
| Other names: |
N-Sec1, Protein unc-18 homolog 1, Protein unc-18 homolog A, Syntaxin-binding protein 1, Unc-18A, Unc18-1, p67, p67, protein unc-18 homolog 1, protein unc-18 homolog A, rbSec1, syntaxin binding protein 1, syntaxin-binding protein 1, unc-18 homolog, unc-18-1, unc-18A, syntaxin-binding protein 1 |
| Gene name: |
MUNC-18 |
| Other gene names: |
ANC18HA, Munc18-1, NSEC1A, Sec1, Stxbp1, Unc-18A, Unc18-1, Unc18-1, Unc18a, n-sec1, nSec1, rbSec1, rbSec1A, rbSec1B, Stxbp1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Rat |
| Specificity and cross-reactivity: |
It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding, It is neural specific, Munc-18 is crucial to calcium-dependent neurotransmitter release, The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C, _x000D__x000D_Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release, a 67 kDa member of the STXBP/UNC-18/SEC1 family, expressed in the brain, facilitating synaptic vesicle docking and fusion, spinal cord and at very high levels in axons, MUNC-18 This item recognises Munc-18 phosphorylated at serine 515 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 12 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
MUNC-18 (pSer515) |
| Short name: |
Anti-MUNC-18 (pSer515) |
| Alternative name: |
antibody to-MUNC-18 (pSer515) |