| known also as: |
Anti-RABBIT ANTI BMI-1 |
| known also as: |
RABBIT ANTI BMI-1 |
| known also as: |
Lapin ANTI BMI-1 |
| known also as: |
BMI-1 |
| Other names: |
COMMD3-BMI1 read-through protein, N/A, Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, COMMD3-BMI1 read-through protein |
| Gene name: |
BMI-1 |
| Other gene names: |
BMI1, N/A, PCGF4, RNF51, COMMD3-BMI1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
BMI-1 is a proto-oncogene which cooperates with the myc oncogene to produce B-lymphomas, BMI-1 is also required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2 within the PRC1 complex, BMI-1 represses transcription at the ink4 locus which contains tumour suppressors p16 and p19Arf, It is required in the regulation of normal adult and leukaemic stem cells, Recent studies have shown that the Notch ligand DLL4 (delta-like protein 4) enhances T cell proliferation, _x000D__x000D_BMI-1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex which ubiquitinates histone-2A at lys119, by directly influencing BMI-1 transcription, cell growth and maintenance, involved in segment specification, making BMI-1 a potential target for stem cell proliferation and anti-cancer therapies, resulting in a heritable change in the ability of chromatin to express genes, transcriptional regulation and chromatin modification, BMI-1 This item recognises 37kDa polycomb complex protein BMI-1 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunohistology - Frozen (IHC), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
BMI-1 |
| Short name: |
Anti-BMI-1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-BMI-1 (Antibody to) |
| Alternative technique: |
antibodies |