| known also as: |
Anti-RABBIT ANTI HUMAN WNK1 |
| known also as: |
RABBIT ANTI HUMAN WNK1 |
| known also as: |
Lapin ANTI Homo sapiens WNK1 |
| known also as: |
WNK1 |
| Other names: |
Erythrocyte 65 kDa protein, Kinase deficient protein, Protein kinase lysine-deficient 1, Protein kinase with no lysine 1, Serine/threonine-protein kinase WNK1, WNK lysine deficient protein kinase 1, WNK lysine deficient protein kinase 1 isoform, erythrocyte 65 kDa protein, p65, prostate-derived sterile 20-like kinase, protein kinase with no lysine 1, serine/threonine-protein kinase WNK1, serine/threonine-protein kinase WNK1 isoform 4 |
| Gene name: |
WNK1 |
| Other gene names: |
HSAN2, HSN2, HSN2, KDP, KDP, KIAA0344, PRKWNK1, PRKWNK1, PSK, WNK1, hWNK1, p65, p65, WNK1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Alternative splicing of WNK1 produces a kidney-specific short form that lacks a kinase domain, KS-WNK1, L-WNK1, _x000D__x000D_WNK1 and WNK4 have been identified as the dysregulated genes in Gordon's syndrome (pseudohypoaldosteronism type 2 [PHA2]) which affects salt homeostasis by the kidney, a 250kD cytoplasmic serine/threonine kinase which regulates the activity of a number of ion transporters, and a more ubiquitous long form, and thus has an important role in blood pressure and ion homeostasis, WNK1 This item detects an epitope within the internal region (IN) of WNK1 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunohistology - Paraffin (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
WNK1 |
| Short name: |
Anti-HUMAN WNK1 |
| Alternative name: |
sapiens WNK lysine deficient protein kinase 1, antibody to-H |
| Alternative to gene target: |
Cytoplasm, WNK1 and IDBG-11521 and ENSG00000060237 and 65125, WNK1 and IDBG-641017 and ENSBTAG00000005221 and 506433, Wnk1 and IDBG-183036 and ENSMUSG00000045962 and 232341, this GO :0003084 and positive regulation of systemic arterial blood pressure and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006811 and ion transport and biological process this GO :0010923 and negative regulation of phosphatase activity and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004860 : protein kinase inhibitor activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004860 : protein kinase inhibitor activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0019869 : chloride channel inhibitor activity, this GO :0019902 : phosphatase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019869 : chloride channel inhibitor activity and also this GO :0019902 : phosphatase binding, transferring phosphorus-containing groups and molecular function this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0019869 and chloride channel inhibitor activity and molecular function this GO :0019902 and phosphatase binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0048666 and neuron development and biological process this GO :0050794 and regulation of cellular process and biological process this GO :0090188 and negative regulation of pancreatic juice secretion and biological process, WNK lysine deficient protein kinase 1 |
| Identity: |
14540 |
| Gene: |
WNK1 |
More about : WNK1 |
| Long gene name: |
WNK lysine deficient protein kinase 1 |
| Synonyms gene: |
PRKWNK1 HSN2 |
| Synonyms gene name: |
lysine deficient 1 hereditary sensory neuropathy, protein kinase, type II |
| Synonyms: |
HSAN2 PPP1R167 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 167 |
| Locus: |
12p13, 33 |
| Discovery year: |
2001-02-06 |
| GenBank acession: |
AJ296290 |
| Entrez gene record: |
65125 |
| RefSeq identity: |
NM_018979 |
| Classification: |
Minor histocompatibility antigens Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000090321 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_247 |