| known also as: |
Anti-RABBIT ANTI HUMAN ErbB4 |
| known also as: |
RABBIT ANTI HUMAN ErbB4 |
| known also as: |
Lapin ANTI Homo sapiens ErbB4 |
| known also as: |
ErbB4 |
| Other names: |
4ICD, Alternative name(s):, E4ICD, Proto-oncogene-like protein c-ErbB-4, Receptor tyrosine-protein kinase erbB-4, Tyrosine kinase-type cell surface receptor HER4, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4, p180erbB4Cleaved into the following chain:ERBB4 intracellular domain, proto-oncogene-like protein c-ErbB-4, receptor tyrosine-protein kinase erbB-4, s80HER4, tyrosine kinase-type cell surface receptor HER4, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), receptor tyrosine-protein kinase erbB-4 isoform JM-a/CVT-2 |
| Gene name: |
ErbB4 |
| Other gene names: |
4ICD, E4ICD, ERBB4, HER4, HER4, p180erbB4, ERBB4 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
ErbB4 is activated by a number of factors including neuregulins and betacellulin, In the cell, This fragment translocates to the nucleus and induces cell proliferation and differentiation, _x000D__x000D_ErbB4 is important in embryonic development, a transmembrane protein which is a member of the epidermal growth factor receptor subfamily, and mutations to its gene have been associated with cancer, the remaining 80kD fragment of ErbB4 is internalised and cleaved by gamma-secretase, which leads to the cleavage of a 120kD ectodomain fragment by TACE, ErbB4 This item detects an epitope within the internal region of human ErbB4 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunohistology - Paraffin (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
ErbB4 |
| Short name: |
Anti-HUMAN ErbB4 |
| Alternative name: |
sapiens v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), antibody to-H |
| Identity: |
3432 |
| Gene: |
ERBB4 |
More about : ERBB4 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms gene name: |
v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
| Synonyms: |
ALS19 HER4 |
| Synonyms name: |
human epidermal growth factor receptor 4 |
| Locus: |
2q34 |
| Discovery year: |
1995-09-07 |
| GenBank acession: |
L07868 |
| Entrez gene record: |
2066 |
| Pubmed identfication: |
7700649 17018285 |
| RefSeq identity: |
NM_001042599 |
| Classification: |
Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000133012 |