| known also as: |
Anti-GOAT ANTI ErbB3 (C-TERMINAL) |
| known also as: |
Caprine ANTI ErbB3 (C-TERMINAL) |
| known also as: |
Caprinae ANTI ErbB3 (C-TERMINAL) |
| known also as: |
ErbB3 |
| Other names: |
Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, proto-oncogene-like protein c-ErbB-3, receptor tyrosine-protein kinase erbB-3, tyrosine kinase-type cell surface receptor HER3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian), receptor tyrosine-protein kinase erbB-3 isoform s |
| Gene name: |
ErbB3 |
| Other gene names: |
ERBB3, ErbB-3, HER3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, ERBB3 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Goat |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, Heterodimerization leads to the activation of cellular pathways, In breast cancer it has been shown to dimerize with ErbB2 to drive tumour cell proliferation, This membrane-bound protein has a neuregulin binding domain but not an active kinase domain, _x000D__x000D_Amplification of this gene and/or over expression of its protein has been reported in numerous cancers, and breast tumors, and can therefore only convey the signal through heterodimerisation with other EGF receptor family members which do have kinase activity, and has a molecular weight of 150kD, bladder, including prostate, thus leading to proliferation or differentiation, ErbB3 This item detects an epitope within the C-terminal (CT) region of ErbB3 isoform 1 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
5 mg/ml, IgG concentration 0 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
ELISA (EIA), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
ErbB3 |
| Short name: |
GOAT ANTI ErbB3 (C-TERMINAL) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
caprine antibody to v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (C-TERMINAL) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3431 |
| Gene: |
ERBB3 |
More about : ERBB3 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 3 |
| Synonyms gene: |
LCCS2 |
| Synonyms gene name: |
lethal congenital contracture syndrome 2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 |
| Synonyms: |
HER3 |
| Synonyms name: |
human epidermal growth factor receptor 3 |
| Locus: |
12q13, 2 |
| Discovery year: |
1990-07-15 |
| GenBank acession: |
M34309 |
| Entrez gene record: |
2065 |
| RefSeq identity: |
NM_001982 |
| Classification: |
Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000170140 |
| Locus Specific Databases: |
LRG_996 |