| known also as: |
Anti-RABBIT ANTI HUMAN ANDROGEN RECEPTOR |
| known also as: |
RABBIT ANTI HUMAN ANDROGEN RECEPTOR |
| known also as: |
Lapin ANTI Homo sapiens ANDROGEN RECEPTOR |
| known also as: |
ANDROGEN RECEPTOR |
| Other names: |
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, androgen nuclear receptor variant 2, androgen receptor, androgen receptor, dihydrotestosterone receptor, nuclear receptor subfamily 3 group C member 4, androgen receptor isoform 1 |
| Other gene names: |
AIS, AR, DHTR, DHTR, HUMARA, HYSP1, KD, NR3C4, NR3C4, SBMA, SMAX1, TFM, AR |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
AR homodimers recruit a variety of factors including coactivators and mediator proteins whose enzymatic activities promote chromatin remodeling and transcriptional regulation of target genes leading to cell differentiation, AR mutations can also cause spinal bulbar muscular atrophy (Kennedy disease) and partial/ complete androgen insensitivity, Dihydrotestosterone (DHT) binds with highest affinity to AR and together with testosterone promotes AR transcriptional activity thereby ensuring the development and maintenance of male reproductive functions, Mutated AR is strongly implicated in development of prostate adenocarcinoma and metastases development, and proliferation, survival, ANDROGEN RECEPTOR This item is specific for Androgen Receptor (AR) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 5 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunohistology - Paraffin (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
ANDROGEN RECEPTOR |
| Short name: |
Anti-HUMAN ANDROGEN RECEPTOR |
| Alternative name: |
sapiens ANDROGEN RECEPTOR, antibody to-H |
| Identity: |
644 |
| Gene: |
AR |
More about : AR |
| Long gene name: |
androgen receptor |
| Synonyms gene: |
DHTR SBMA |
| Synonyms gene name: |
dihydrotestosterone receptor spinal and bulbar muscular atrophy |
| Synonyms: |
AIS NR3C4 SMAX1 HUMARA |
| Synonyms name: |
testicular feminization Kennedy disease |
| Locus: |
Xq12 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M20132 |
| Entrez gene record: |
367 |
| Pubmed identfication: |
3353726 3377788 |
| RefSeq identity: |
NM_000044 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000021740 |
| Locus Specific Databases: |
Androgen Receptor Mental Retardation database ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database |