| known also as: |
Anti-RABBIT ANTI HUMAN RANTES:Biotin |
| known also as: |
RABBIT ANTI HUMAN RANTES:Biotin |
| known also as: |
Lapin ANTI Homo sapiens RANTES:Biotin |
| known also as: |
RANTES |
| Other names: |
C-C motif chemokine 5, C-C motif chemokine 5, EoCP, Eosinophil chemotactic cytokine, SIS-delta, SIS-delta, Small-inducible cytokine A5, T cell-specific protein P228, T-cell specific protein p288, T-cell-specific protein RANTES, T-cell-specific protein RANTES, TCP228, and presumably secreted, beta-chemokine RANTES, chemokine (C-C motif) ligand 5, eoCP, eosinophil chemotactic cytokine, member 5, normally T-expressed, regulated upon activation, small inducible cytokine A5 (RANTES), small inducible cytokine subfamily A (Cys-Cys), small-inducible cytokine A5, t cell-specific protein P228, C-C motif chemokine 5 |
| Gene name: |
RANTES |
| Other gene names: |
CCL5, D17S136E, D17S136E, RANTES, SCYA5, SCYA5, SISd, TCP228, TCP228, CCL5 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Both CCR3 and CCR5 are known co-receptors for the entry of HIV viruses into target cells and the binding of RANTES to CCR3 on CTLs has been shown to enhance HIV-1-specific cytotoxicity, CCR3 and CCR5, CD4+/CD45RO+ memory T cells, _x000D__x000D_RANTES acts as a chemoattractant for monocytes, a 68 amino acid CC- chemokine involved in T cell activation and cell recruitment, basophils and eosinophils, expressed by cytotoxic (CD8+) T cells (CTLs), keratinocytes and endothelial cells, macrophages, normal T cell expressed and secreted), otherwise known as CCL5, thorough binding to chemokine (C-C motif) receptor 1 (CCR1), whilst binding to CCR5 inhibits membrane fusion and hence HIV entry, RANTES This item is specific for human RANTES (regulated upon activation |
| Form/Appearance: |
Biotin (Purified IgG conjugated to Biotin - lyophilised) |
| Concentration: |
1 miligram per 1 mililiter after reconstitution, IgG concentration 0 |
| Storage and shipping: |
After reconstitution For optimal long term storage, Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 12 months from date of reconstitution, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, productone should be kept at -20 degrees Celsius, productone should be stored undiluted, Prior to reconstitution store at +Store productone at +4 degrees Celsius |
| Tested for:: |
ELISA (EIA), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, Biotin conjugates can be detected by horseradish peroxidase |
| Conjugation: |
Biotinylated |
| Gene target: |
RANTES: |
| Short name: |
Anti-HUMAN RANTES: |
| Label: |
Biotin |
| Alternative name: |
sapiens RANTES:biotinilated, antibody to-H |
| Identity: |
10632 |
| Gene: |
CCL5 |
More about : CCL5 |
| Long gene name: |
C-C motif chemokine ligand 5 |
| Synonyms gene: |
D17S136E SCYA5 |
| Synonyms gene name: |
small inducible cytokine A5 (RANTES) chemokine (C-C motif) ligand 5 |
| Synonyms: |
RANTES SISd TCP228 MGC17164 |
| Synonyms name: |
T-cell specific protein p288 T-cell specific RANTES protein SIS-delta regulated upon activation, and presumably secreted beta-chemokine RANTES small inducible cytokine subfamily A (Cys-Cys), member 5 , normally T-expressed |
| Locus: |
17q12 |
| Discovery year: |
1990-07-05 |
| GenBank acession: |
AF043341 |
| Entrez gene record: |
6352 |
| Pubmed identfication: |
1691736 |
| RefSeq identity: |
NM_002985 |
| Classification: |
Endogenous ligands Chemokine ligands |
| Havana BLAST/BLAT: |
OTTHUMG00000188396 |