| Long name: |
GFI1B Primary Polyclonal Antibody |
| Also known as: |
GFI1B PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
GFI1B |
| Specificity: |
This is a highly specific antibody against GFI1B |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GFI1B |
| Gene ID number: |
8328 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Alters histone methylation by recruiting histone methyltransferase to target genes promoters, Binds to gamma-satellite DNA and to its own promoter, Cooperates with GATA1 to repress target gene transcription, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate, Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells, Plays a role in heterochromatin formation, Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction, Transcriptional repressor or activator depending on both promoter and cell type context, as GATA1 also mediates erythroid GFI1B transcription, auto-repressing its own expression, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells, may regulate cytokine signaling pathways, represses promoter activity of SOCS1 and SOCS3 and thus, such as the apoptosis regulator BCL2L1, Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
GFI 1B, GFI-1B, GFI1B protein, GFI1B_HUMAN, Growth factor independent 1B protein, Growth factor independent protein 1B, Potential regulator of CDKN1A, Translocated in CML, Zinc finger protein Gfi-1b, gfi1b, Potential regulator of CDKN1A translocated in CML |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GFI1B |
| Short name: |
GFI1B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GFI1B (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4238 |
| Gene: |
GFI1B |
More about : GFI1B |
| Long gene name: |
growth factor independent 1B transcriptional repressor |
| Synonyms gene name: |
growth factor independent 1B (potential regulator of CDKN1A, translocated in CML) |
| Synonyms: |
ZNF163B |
| Locus: |
9q34, 13 |
| Discovery year: |
1998-09-17 |
| GenBank acession: |
AF081946 |
| Entrez gene record: |
8328 |
| Pubmed identfication: |
9878267 |
| RefSeq identity: |
NM_004188 |
| Classification: |
Zinc fingers C2H2-type SNAG transcriptional repressors |
| Havana BLAST/BLAT: |
OTTHUMG00000020848 |
| Locus Specific Databases: |
LRG_879 |