| Long name: |
ALEXA FLUOR 647 Conjugated, SH2D1A Polyclonal Antibody |
| Also known as: |
Anti-SH2D1A PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SH2D1A |
| Specificity: |
This is a highly specific antibody against SH2D1A |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SH2D1A/SAP |
| Gene ID Number: |
4068 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains, CD229 (LY9) and CD244 (2B4), CD45RA+ and CD8+, CD45RO+, CD84, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), SH2D1A is a hydrophilic, SH2D1A is present in all major subsets of T cells, SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM, SLAM activation mediates expansion of activated T cells during immune responses, also SH2 domain protein 1A, but not in B cells, including CD4+, induces production of interferon-?and changes the functional profile of subsets of T cells, influences signaling pathways involving SLAM molecules at the interface between T and B cells, SH2D1A |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
XLP MTCP1 DSHP XLPD EBVS SAP |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the SH2D1A Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
SH2D1A |
| Short name: |
SH2D1A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, SH2 domain containing 1A (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cytoplasm, DSHP and EBVS and IMD5 and LYP and MTCP1 and SAP and SAP/SH2D1A and XLP and XLPD and XLPD1, SH2D1A and IDBG-630222 and ENSBTAG00000026067 and 613356, SH2D1A and IDBG-85368 and ENSG00000183918 and 4068, Sh2d1a and IDBG-141610 and ENSMUSG00000005696 and 20400, protein binding, this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006959 and humoral immune response and biological process this GO :0006968 and cellular defense response and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0045087 and innate immune response and biological process this GO :0045954 and positive regulation of natural killer cell mediated cytotoxicity and biological process, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, SH2 domain containing 1A |
| Identity: |
10820 |
| Gene: |
SH2D1A |
More about : SH2D1A |
| Long gene name: |
SH2 domain containing 1A |
| Synonyms gene: |
IMD5 LYP |
| Synonyms gene name: |
lymphoproliferative syndrome SH2 domain protein 1A |
| Synonyms name: |
Duncan', s disease |
| Locus: |
Xq25 |
| Discovery year: |
1989-06-30 |
| GenBank acession: |
AL023657 |
| Entrez gene record: |
4068 |
| Pubmed identfication: |
9771704 9774102 |
| RefSeq identity: |
NM_002351 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000022344 |
| Locus Specific Databases: |
SH2D1Abase: Mutation registry for X-linked lymphoproliferative syndrome (XLP) LRG_106 |