| Long name: |
ALEXA FLUOR 555 Conjugated, PMS1 Polyclonal Antibody |
| Also known as: |
Anti-PMS1 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PMS1 |
| Specificity: |
This is a highly specific antibody against PMS1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PMS1 |
| Gene ID Number: |
5378 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Initially, The demonstration that 10 to 45% of pancreatic, Two additional homologs of the prokaryotic MutL gene, breast, designated PMS1 and PMS2, gastric, have been identified and shown to be mutated in the germline of HNPCC patients, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression, The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
MLH2 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
PMS1 |
| Short name: |
PMS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, PMS1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9121 |
| Gene: |
PMS1 |
More about : PMS1 |
| Long gene name: |
PMS1 homolog 1, mismatch repair system component |
| Synonyms gene: |
PMSL1 |
| Synonyms gene name: |
cerevisiae) , cerevisiae) 1 PMS1 postmeiotic segregation increased 1 (S, postmeiotic segregation increased (S |
| Locus: |
2q32, 2 |
| Discovery year: |
1994-12-13 |
| Entrez gene record: |
5378 |
| Pubmed identfication: |
8072530 23608172 |
| RefSeq identity: |
NM_000534 |
| Classification: |
MutL homologs |
| Havana BLAST/BLAT: |
OTTHUMG00000132664 |
| Locus Specific Databases: |
HNPCC Colon cancer gene variant databases PMS1 database at LOVD-China LRG_221 , Hereditary Non-Polyposis Colorectal Cancer |