| Long name: |
Biotin Conjugated, UBE2O Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
UBE2O |
| Specificity: |
This is a highly specific antibody against UBE2O |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human UBE2O/E2 230K |
| Gene ID number: |
63893 |
| Tested applications: |
IHC-P |
| Recommended dilutions: |
IHC-P(1:100-500) |
| Crossreactivity: |
Rat, Mouse |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
BRCA1 is directly involved in DNA repair, Expressed predominately in heart and skeletal muscle, Like p53, Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome, The gene encoding UBE2O maps to human chromosome 17, Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death, Two key tumor suppressor genes are associated with chromosome 17, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, also known as E2-230K, colon, is a 1, namely, p53 and BRCA1, prostate gland and fallopian tubes, thereby targeting the ubiquitinated proteins for proteasomal degradation, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, which comprises over 2, 200 genes, 292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification, 5% of the human genome and encodes over 1, UBE20 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
E2-230K |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UBE2O Conjugated |
| Short name: |
Conjugated, UBE2O Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, UBE2O (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
29554 |
| Gene: |
UBE2O |
More about : UBE2O |
| Long gene name: |
ubiquitin conjugating enzyme E2 O |
| Synonyms gene name: |
ubiquitin-conjugating enzyme E2O |
| Locus: |
17q25, 1 |
| Discovery year: |
2005-12-15 |
| GenBank acession: |
AB051521 |
| Entrez gene record: |
63893 |
| Pubmed identfication: |
11311559 11214970 |
| RefSeq identity: |
NM_022066 |
| Havana BLAST/BLAT: |
OTTHUMG00000180178 |