| Long name: |
HIP2 Primary Polyclonal Antibody |
| Also known as: |
HIP2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HIP2 |
| Specificity: |
This is a highly specific antibody against HIP2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
69-93/200 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HIP2 |
| Gene ID number: |
3093 |
| Swiss Prot: |
P61086 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein, In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol, In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1, In vitro, May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53, Mediates the selective degradation of short-lived and abnormal proteins, Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B, Ubiquitinates huntingtin, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, in vitro supports ubiquitination of NFKB1, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins, Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
E2-25K, HIP-2, HIP2, HYPG, Huntingtin-interacting protein 2, UBC1, UBE2K, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2 K, Ubiquitin-conjugating enzyme E2(25K), Ubiquitin-conjugating enzyme E2-25 kDa, Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-protein ligase, LIG |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HIP2 |
| Short name: |
HIP2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HIP2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4914 |
| Gene: |
UBE2K |
More about : UBE2K |
| Long gene name: |
ubiquitin conjugating enzyme E2 K |
| Synonyms gene: |
HIP2 |
| Synonyms gene name: |
huntingtin interacting protein 2 ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) ubiquitin-conjugating enzyme E2K |
| Synonyms: |
HYPG UBC1 |
| Locus: |
4p14 |
| Discovery year: |
1997-08-28 |
| GenBank acession: |
U58522 |
| Entrez gene record: |
3093 |
| Pubmed identfication: |
8702625 17873885 |
| RefSeq identity: |
NM_005339 |
| Classification: |
Ubiquitin conjugating enzymes E2 |
| Havana BLAST/BLAT: |
OTTHUMG00000160543 |