| Long name: |
UBE2D3 Primary Polyclonal Antibody |
| Also known as: |
UBE2D3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
UBE2D3 |
| Specificity: |
This is a highly specific antibody against UBE2D3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UBE2D3 |
| Gene ID number: |
7323 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts also as an initiator E2, Acts as an initiator E2, Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair, Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation, In conjunction with the CBL E3 ligase, In conjunction with the MDM2 and TOPORS E3 ligases, In conjunction with the STUB1 E3 quality control E3 ligase, In vitro catalyzes 'Lys-11'-, Monoubiquitination of PCNA, Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis, Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus, Ubiquitin chain elongation is then performed by CDC34, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase, as well as 'Lys-48'-linked polyubiquitination, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin, for the priming of PCNA, functions ubiquitination of p53/TP53, in conjunction with RNF8, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes, ubiquitinates unfolded proteins to catalyze their immediate destruction, Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
MGC43926, MGC5416, UB2D3_HUMAN, UBC 4/5, UBC4/5, UBC4/5 homolog yeast, UBCH 5C, UBCH5C, Ube2d3, Ubiquitin carrier protein, Ubiquitin carrier protein D3, Ubiquitin conjugating enzyme E2 17 kDa 3, Ubiquitin conjugating enzyme E2 D3, Ubiquitin conjugating enzyme E2D 3, Ubiquitin conjugating enzyme E2D 3 UBC4/5 homolog yeast, Ubiquitin conjugating enzyme E2D 3 homologous to yeast UBC4/5, Ubiquitin protein ligase D3, Ubiquitin-conjugating enzyme E2 D3, Ubiquitin-conjugating enzyme E2-17 kDa 3, Ubiquitin-conjugating enzyme E217KB 3, Ubiquitin-protein ligase D3, E217KB3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UBE2D3 |
| Short name: |
UBE2D3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ubiquitin-conjugating enzyme E2D 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0006464 and cellular protein modification process and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006513 and protein monoubiquitination and biological process this GO :0006915 and apoptotic process and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0008152 and metabolic process and biological process this GO :0010008 and endosome membrane and cellular component this GO :0010467 and gene expression and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0016881 and acid-amino acid ligase activity and molecular function this GO :0030509 and BMP signaling pathway and biological process this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0043161 and proteasome-mediated ubiquitin-dependent protein catabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0070936 and protein K48-linked ubiquitination and biological process this GO :0070979 and protein K11-linked ubiquitination and biological process this GO :0071456 and cellular response to hypoxia and biological process, E2(17)KB3 and UBC4/5 and UBCH5C, IDBG-639940 and IDBG-639940 and ENSBTAG00000045753 and, UBE2D3 and IDBG-32113 and ENSG00000109332 and 7323, Ube2d3 and IDBG-269073 and ENSMUSG00000078578 and 66105, acid-amino acid ligase activity, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000209 and protein polyubiquitination and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005654 and nucleoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006281 and DNA repair and biological process this GO :0006351 and transcription, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016881 : acid-amino acid ligase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016881 : acid-amino acid ligase activity, ubiquitin-conjugating enzyme E2D 3 |
| Identity: |
12476 |
| Gene: |
UBE2D3 |
More about : UBE2D3 |
| Long gene name: |
ubiquitin conjugating enzyme E2 D3 |
| Synonyms gene name: |
ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5) ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) ubiquitin-conjugating enzyme E2D 3 |
| Synonyms: |
UbcH5C |
| Locus: |
4q24 |
| Discovery year: |
1997-03-21 |
| GenBank acession: |
U39318 |
| Entrez gene record: |
7323 |
| Pubmed identfication: |
8530467 |
| RefSeq identity: |
NM_181893 |
| Classification: |
Ubiquitin conjugating enzymes E2 |
| Havana BLAST/BLAT: |
OTTHUMG00000131119 |