| Long name: |
ALEXA FLUOR 488 Conjugated, TMEM173 Polyclonal Antibody |
| Also known as: |
Anti-TMEM173 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
TMEM173 |
| Specificity: |
This is a highly specific antibody against TMEM173 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
260-310/379 |
| Subcellular location: |
Intracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TMEM173 |
| Gene ID Number: |
340061 |
| Swiss Prot: |
Q86WV6 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression, Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm, May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II), May be involved in translocon function, Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway, the translocon possibly being able to influence the induction of type I interferons, Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta) |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
FLJ38577 NET23 ERIS MPYS STING MITA |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the TMEM173 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
TMEM173 |
| Short name: |
TMEM173 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, transmembrane protein 173 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, TMEM173 and IDBG-47893 and ENSG00000184584 and 340061, TMEM173 and IDBG-646026 and ENSBTAG00000002296 and 533661, Tmem173 and IDBG-137341 and ENSMUSG00000024349 and 72512, cyclic-GMP-AMP binding, this GO :0002218 and activation of innate immune response and biological process this GO :0002230 and positive regulation of defense response to virus by host and biological process this GO :0005515 and protein binding and molecular function this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005777 and peroxisome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0016021 and integral component of membrane and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030659 and cytoplasmic vesicle membrane and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032092 and positive regulation of protein binding and biological process this GO :0032479 and regulation of type I interferon production and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032608 and interferon-beta production and biological process this GO :0033160 and positive regulation of protein import into nucleus, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0019901 : protein kinase binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0035438 : cyclic-di-GMP binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0061507 : cyclic-GMP-AMP binding, this GO :0008134 : transcription factor binding, this GO :0019901 : protein kinase binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0035438 : cyclic-di-GMP binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0061507 : cyclic-GMP-AMP binding, translocation and biological process this GO :0035438 and cyclic-di-GMP binding and molecular function this GO :0035458 and cellular response to interferon-beta and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042993 and positive regulation of transcription factor import into nucleus and biological process this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051607 and defense response to virus and biological process this GO :0061507 and cyclic-GMP-AMP binding and molecular function this GO :0071360 and cellular response to exogenous dsRNA and biological process, transmembrane protein 173 |
| Identity: |
27962 |
| Gene: |
TMEM173 |
More about : TMEM173 |
| Long gene name: |
transmembrane protein 173 |
| Synonyms name: |
stimulator of interferon genes |
| Locus: |
5q31, 2 |
| Discovery year: |
2006-08-24 |
| Entrez gene record: |
340061 |
| Pubmed identfication: |
21947006 |
| RefSeq identity: |
NM_198282 |
| Havana BLAST/BLAT: |
OTTHUMG00000129239 |