| Long name: |
ARRDC3 Primary Polyclonal Antibody |
| Also known as: |
ARRDC3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ARRDC3 |
| Specificity: |
This is a highly specific antibody against ARRDC3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ARRDC3 corresponding to amino acids 178-215 |
| Gene ID number: |
57561 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors (GPCRs), Different arrestins (visual arrestin (or Arrestin 1), GPCRs activate a heterotrimeric G protein, In order to turn off this response, In response to a stimulus, Once arrestin is bound to the receptor it is unable to signal further, Recent research continues to expand the known actions of arrestins, The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs), This phosphorylation specifically marks the activated receptor for arrestin binding, activated receptors need to be silenced, beta-arrestin 1 (or Arrestin 2) and beta-arrestin 2 (or Arrestin 3) can reduce the activity of their target GPCRs in several different ways, or adapt to a constant stimulus, which can bind to other classes of receptors and can directly activate signaling pathways on their own, The arrestins are a family of proteins that are important for regulating signal transduction within cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ARRD3_HUMAN, Arrestin domain containing protein 3, KIAA1376, TLIMP, Thioredoxin binding protein 2 like inducible membrane, ARRDC 3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ARRDC3 |
| Short name: |
ARRDC3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ARRDC3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
29263 |
| Gene: |
ARRDC3 |
More about : ARRDC3 |
| Long gene name: |
arrestin domain containing 3 |
| Synonyms: |
KIAA1376 TLIMP |
| Synonyms name: |
alpha-arrestin 3 TBP-2-like inducible membrane protein |
| Locus: |
5q14, 3 |
| Discovery year: |
2004-02-11 |
| GenBank acession: |
AB037797 |
| Entrez gene record: |
57561 |
| Pubmed identfication: |
10718198 19605364 |
| RefSeq identity: |
NM_020801 |
| Classification: |
Alpha arrestins |
| Havana BLAST/BLAT: |
OTTHUMG00000162616 |