| Long name: |
Cy5, 5 Conjugated, SAMHD1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SAMHD1 |
| Specificity: |
This is a highly specific antibody against SAMHD1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human SAMHD1 |
| Gene ID number: |
4861 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
A form of Aicardi-Goutieres syndrome, Clinical features as thrombocytopenia, Death often occurs in early childhood, May play a role in mediating proinflammatory responses to TNF-alpha signaling, No expression is seen in brain and thymus, Severe neurological dysfunctions manifest in infancy as progressive microcephaly, a genetically heterogeneous disease characterized by cerebral atrophy, and negative serologic investigations for common prenatal infection, chronic cerebrospinal fluid (CSF) lymphocytosis, dystonic posturing and profound psychomotor retardation, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process, increased CSF alpha-interferon, intracranial calcifications, leukoencephalopathy, liver, lung and peripheral blood leukocytes, placenta, skeletal muscle, small intestine, spasticity, spleen, Involvement in disease:Defects in SAMHD1 are the cause of Aicardi-Goutieres syndrome type 5 (AGS5) , Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response, Tissue specificity:Expressed in heart |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
SBBI88 Mg11 HDDC1 MOP-5 AGS5 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
SAMHD1 Conjugated |
| Short name: |
Conjugated, SAMHD1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, SAMHD1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
15925 |
| Gene: |
SAMHD1 |
More about : SAMHD1 |
| Long gene name: |
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
| Synonyms gene name: |
SAM domain and HD domain 1 |
| Synonyms name: |
HD domain containing 1 monocyte protein 5 Aicardi-Goutieres syndrome 5 |
| Locus: |
20q11, 23 |
| Discovery year: |
2001-07-31 |
| GenBank acession: |
AF228421 |
| Entrez gene record: |
25939 |
| Pubmed identfication: |
11064105 11230166 22056990 |
| RefSeq identity: |
NM_015474 |
| Classification: |
Sterile alpha motif domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000032402 |
| Locus Specific Databases: |
LRG_281 |