| Long name: |
BAG6 Primary Polyclonal Antibody |
| Also known as: |
BAG6 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
BAG6 |
| Specificity: |
This is a highly specific antibody against BAG6 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human BAT3/BAG6 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts in part by regulating stability of proteins and their degradation by the proteasome, Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, In this context, Key component of the BAG6/BAT3 complex, Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation, Required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome, TA membrane proteins, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane, also named type II transmembrane proteins, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2, contain a single C-terminal transmembrane region, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response, Chaperone that plays a key role in various processes such as apoptosis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BAG-6, BAG6, BAG6_HUMAN, BCL2-associated athanogene 6, Bag6, D6S52E, G3, HLA B associated transcript 3, HLA-B-associated transcript 3, Large proline-rich protein BAG6, Protein G3, Protein Scythe, family molecular chaperone regulator 6 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
BAG6 |
| Short name: |
BAG6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
B-cell CLL/lymphoma 2-associated athanogene 6 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BAG-6 and BAT3 and D6S52E and G3, BAG6 and IDBG-125033 and ENSG00000204463 and 7917, BT, Bag6 and IDBG-176819 and ENSMUSG00000024392 and 224727, nuclei, proteasome binding, this GO :0001822 and kidney development and biological process this GO :0002376 and immune system process and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006810 and transport and biological process this GO :0007130 and synaptonemal complex assembly and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007420 and brain development and biological process this GO :0009790 and embryo development and biological process this GO :0016568 and chromatin modification and biological process this GO :0018393 and internal peptidyl-lysine acetylation and biological process this GO :0030154 and cell differentiation and biological process this GO :0030324 and lung development and biological process this GO :0030544 and Hsp70 protein binding and molecular function this GO :0031593 and polyubiquitin binding and molecular function this GO :0032435 and negative regulation of proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0043022 and ribosome binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045861 and negative regulation of proteolysis and biological process this GO :0050821 and protein stabilization and biological process this GO :0070059 and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process this GO :0070628 and proteasome binding and molecular function this GO :0071816 and tail-anchored membrane protein insertion into ER membrane and biological process this GO :0071818 and BAT3 complex and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0030544 : Hsp70 protein binding and also this GO :0031593 : polyubiquitin binding and also this GO :0043022 : ribosome binding and also this GO :0070628 : proteasome binding, this GO :0030544 : Hsp70 protein binding, this GO :0031593 : polyubiquitin binding, this GO :0043022 : ribosome binding, this GO :0070628 : proteasome binding, 23547 and IDBG-634053 and ENSBTAG00000019685 and 508605, BCL2-associated athanogene 6 |
| Identity: |
13919 |
| Gene: |
BAG6 |
More about : BAG6 |
| Long gene name: |
BCL2 associated athanogene 6 |
| Synonyms gene: |
BAT3 |
| Synonyms gene name: |
HLA-B associated transcript 3 |
| Synonyms: |
G3 D6S52E |
| Locus: |
6p21, 33 |
| Discovery year: |
2001-07-13 |
| GenBank acession: |
M31294 |
| Entrez gene record: |
7917 |
| Pubmed identfication: |
2156268 |
| RefSeq identity: |
NM_080703 |
| Classification: |
BCL2 associated athanogene family |
| Havana BLAST/BLAT: |
OTTHUMG00000031171 |