| Long name: |
JMY Primary Polyclonal Antibody |
| Also known as: |
JMY PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
JMY |
| Specificity: |
This is a highly specific antibody against JMY |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
445-475/988 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human JMY |
| Gene ID number: |
133746 |
| Swiss Prot: |
Q8N9B5 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activates the Arp2/3 complex to induce branched actin filament networks, Also catalyzes actin polymerization in the absence of Arp2/3, Contributes to cell motility by controlling actin dynamics, In cytoplasm, In nucleus, Increases p53/TP53-dependent transcription and apoptosis, May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments, The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity), acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300, acts as a nucleation-promoting factor for both branched and unbranched actin filaments, creating unbranched filaments, suggesting an important role in p53/TP53 stress response such as DNA damage, Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
JMY, Junction-mediating and -regulatory protein, WHDC1L3, WHAMM2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
JMY |
| Short name: |
JMY Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
p53 cofactor (Antibody to), junction mediating and regulatory protein |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
JMY and IDBG-30979 and ENSG00000152409 and 133746, JMY and IDBG-645239 and ENSBTAG00000025856 and 101909783, Jmy and IDBG-172833 and ENSMUSG00000021690 and 57748, nuclei, p53 cofactor, protein binding, this GO :0003713 and transcription coactivator activity and molecular function this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006281 and DNA repair and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0031252 and cell leading edge and cellular component this GO :0034314 and Arp2/3 complex-mediated actin nucleation and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0070060 and 'de novo' actin filament nucleation and biological process this GO :0070358 and actin polymerization-dependent cell motility and biological process this GO :0072332 and intrinsic apoptotic signaling pathway by p53 class mediator and biological process, this GO :0003713 : transcription coactivator activity, this GO :0003713 : transcription coactivator activity and also this GO :0003779 : actin binding and also this GO :0005515 : protein binding, this GO :0003779 : actin binding, this GO :0005515 : protein binding, 528498, junction mediating and regulatory protein |
| Identity: |
28916 |
| Gene: |
JMY |
More about : JMY |
| Long gene name: |
junction mediating and regulatory protein, p53 cofactor |
| Synonyms: |
FLJ37870 WHAMM2 |
| Locus: |
5q14, 1 |
| Discovery year: |
2009-02-06 |
| GenBank acession: |
AK095189 |
| Entrez gene record: |
133746 |
| Pubmed identfication: |
10518217 22316129 |
| RefSeq identity: |
NM_152405 |
| Classification: |
Wiskott-Aldrich Syndrome protein family |
| Havana BLAST/BLAT: |
OTTHUMG00000131301 |