| Long name: |
TNIP2 Primary Polyclonal Antibody |
| Also known as: |
TNIP2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TNIP2 |
| Specificity: |
This is a highly specific antibody against TNIP2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
200-230/430 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TNIP2/ABIN2 |
| Gene ID number: |
79155 |
| Swiss Prot: |
Q8NFZ5 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes, Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation, Involved in activation of the MEK/ERK signaling pathway during innate immune response, Involved in regulation of apoptosis in endothelial cells, May act as transcriptional coactivator when translocated to the nucleus, Required for stability of MAP3K8, promotes TEK agonist-stimulated endothelial survival, this function seems to be stimulus- and cell type specific, Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
A20-binding inhibitor of NF-kappa-B activation 2, ABIN-2, ABIN2, FLIP1, Fetal liver LKB1-interacting protein, TNFAIP3-interacting protein 2, TNIP2, KLIP |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TNIP2 |
| Short name: |
TNIP2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TNFAIP3 interacting protein 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0007249 and I-kappaB kinase/NF-kappaB signaling and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0023035 and CD40 signaling pathway and biological process this GO :0031593 and polyubiquitin binding and molecular function this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0043032 and positive regulation of macrophage activation and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050821 and protein stabilization and biological process this GO :0050871 and positive regulation of B cell activation and biological process this GO :0070498 and interleukin-1-mediated signaling pathway and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :2000352 and negative regulation of endothelial cell apoptotic process and biological process, TNIP2 and IDBG-643700 and ENSBTAG00000015126 and 100336382, TNIP2 and IDBG-7609 and ENSG00000168884 and 79155, Tnip2 and IDBG-155271 and ENSMUSG00000059866 and 231130, nuclei, polyubiquitin binding, this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0019901 : protein kinase binding and also this GO :0031593 : polyubiquitin binding, this GO :0019901 : protein kinase binding, this GO :0031593 : polyubiquitin binding, TNFAIP3 interacting protein 2 |
| Identity: |
19118 |
| Gene: |
TNIP2 |
More about : TNIP2 |
| Long gene name: |
TNFAIP3 interacting protein 2 |
| Synonyms: |
ABIN-2 MGC4289 KLIP FLIP1 |
| Locus: |
4p16, 3 |
| Discovery year: |
2002-10-03 |
| GenBank acession: |
BC002740 |
| Entrez gene record: |
79155 |
| Pubmed identfication: |
11390377 12933576 |
| RefSeq identity: |
NM_024309 |
| Havana BLAST/BLAT: |
OTTHUMG00000090267 |