| Long name: |
SIRT4 Primary Polyclonal Antibody |
| Also known as: |
SIRT4 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SIRT4 |
| Specificity: |
This is a highly specific antibody against SIRT4 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
60-110/314 |
| Subcellular location: |
Mitochondrion |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIRT4/SIR 2 like protein 4 |
| Gene ID number: |
23409 |
| Swiss Prot: |
Q9Y6E7 |
| Tested Applications: |
IF(IHC-F), IF(IHC-P), IHC-F, IHC-P, WB |
| Recommended dilutions: |
IF(IHC-F)(1:50-200), IF(IHC-P)(1:50-200), IHC-F(1:100-500), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, Acts as a tumor suppressor, Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, Catalyzes the transfer of ADP-ribosyl groups onto target proteins, Down-regulates insulin secretion, In response to mTORC1 signal, SIRT4 expression is repressed, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity, inhibiting its activity, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest, promoting anaplerosis and cell proliferation, thereby acting as a regulator of lipid homeostasis, Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
NAD-dependent ADP-ribosyltransferase sirtuin-4, NAD-dependent protein deacetylase sirtuin-4, Regulatory protein SIR2 homolog 4, SIR2-like protein 4, SIRT4, SIR2L4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SIRT4 |
| Short name: |
SIRT4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SIRT4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
14932 |
| Gene: |
SIRT4 |
More about : SIRT4 |
| Long gene name: |
sirtuin 4 |
| Synonyms gene name: |
S, cerevisiae, cerevisiae) , homolog) 4 sirtuin (silent mating type information regulation 2 homolog) 4 (S, sirtuin (silent mating type information regulation 2 |
| Synonyms: |
SIR2L4 |
| Locus: |
12q24, 31 |
| Discovery year: |
2001-03-20 |
| GenBank acession: |
AF083109 |
| Entrez gene record: |
23409 |
| Pubmed identfication: |
10381378 |
| RefSeq identity: |
NM_012240 |
| Classification: |
Sirtuins |
| Havana BLAST/BLAT: |
OTTHUMG00000169028 |