| Long name: |
LILRB2 Primary Polyclonal Antibody |
| Also known as: |
LILRB2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
LILRB2 |
| Specificity: |
This is a highly specific antibody against LILRB2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LILRB2 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
B cells, ILT-4, MIR-10 or CD85D antigen, These receptors all contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), When they bind to MHC (or other ligands) and ITIM is tyrosine phosphorylated, also designated LIR-2, competes with CD8A for binding to class I MHC antigens, dendritic cells, have an inhibitory function and are type I membrane proteins, lung and liver, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, protein-tyrosine phosphatases are recruited and an inhibitory signal cascade triggered, Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CD85 antigen-like family member D, CD85d, CD85d antigen, ILT 4, ILT-4, ILT4, Immunoglobulin like transcript 4, Immunoglobulin-like transcript 4, LILRA6, LILRB2, LIR 2, LIR-2, LIR2, LIRB2_HUMAN, LIRb, Leukocyte immunoglobulin like receptor 2, Leukocyte immunoglobulin like receptor subfamily B member 2, Leukocyte immunoglobulin-like receptor, Leukocyte immunoglobulin-like receptor 2, Leukocyte immunoglobulin-like receptor subfamily B member 2, MIR 10, MIR-10, MIR10, Monocyte/macrophage immunoglobulin like receptor 10, Monocyte/macrophage immunoglobulin-like receptor 10, member 2, subfamily B with TM and ITIM domains, CD85D |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
LILRB2 |
| Short name: |
LILRB2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
member 2 (Antibody to), subfamily B (including TM and ITIM domains), leukocyte immunoglobulin-like receptor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD85D and ILT-4 and ILT4 and LIR-2 and LIR2 and MIR-10 and MIR10, Extracellular, LILRB2 and IDBG-68447 and ENSG00000131042 and 10288, cell adhesion molecule binding, member 2, subfamily B (with TM and ITIM domains), this GO :0002578 and negative regulation of antigen processing and presentation and biological process this GO :0002666 and positive regulation of T cell tolerance induction and biological process this GO :0002767 and immune response-inhibiting cell surface receptor signaling pathway and biological process this GO :0002774 and Fc receptor mediated inhibitory signaling pathway and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0006968 and cellular defense response and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0008157 and protein phosphatase 1 binding and molecular function this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0023029 and MHC class Ib protein binding and molecular function this GO :0032396 and inhibitory MHC class I receptor activity and molecular function this GO :0032755 and positive regulation of interleukin-6 production and biological process this GO :0034113 and heterotypic cell-cell adhesion and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042130 and negative regulation of T cell proliferation and biological process this GO :0042288 and MHC class I protein binding and molecular function this GO :0045591 and positive regulation of regulatory T cell differentiation and biological process this GO :0050776 and regulation of immune response and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0051926 and negative regulation of calcium ion transport and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :2001198 and regulation of dendritic cell differentiation and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0008157 : protein phosphatase 1 binding and also this GO :0023029 : MHC class Ib protein binding and also this GO :0032396 : inhibitory MHC class I receptor activity and also this GO :0042288 : MHC class I protein binding and also this GO :0050839 : cell adhesion molecule binding, this GO :0005515 : protein binding, this GO :0008157 : protein phosphatase 1 binding, this GO :0023029 : MHC class Ib protein binding, this GO :0032396 : inhibitory MHC class I receptor activity, this GO :0042288 : MHC class I protein binding, this GO :0050839 : cell adhesion molecule binding, leukocyte immunoglobulin-like receptor |
| Identity: |
6606 |
| Gene: |
LILRB2 |
More about : LILRB2 |
| Long gene name: |
leukocyte immunoglobulin like receptor B2 |
| Synonyms gene name: |
leukocyte immunoglobulin-like receptor, member 2 , subfamily B (with TM and ITIM domains) |
| Synonyms: |
LIR-2 ILT4 MIR-10 LIR2 CD85d MIR10 |
| Synonyms name: |
myeloid inhibitory receptor 10 leucocyte Ig-like receptor B2 |
| Locus: |
19q13, 4 |
| Discovery year: |
2000-01-11 |
| GenBank acession: |
AF000574 |
| Pubmed identfication: |
9151699 9079806 |
| Classification: |
Inhibitory leukocyte immunoglobulin like receptors CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000064896 |