| Long name: |
ALEXA FLUOR 647 Conjugated, FOXO1 + FOXO3 + FOXO4 Antibody |
| Also known as: |
Anti-FOXO1 + FOXO3 + FOXO4 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FOXO1 + FOXO3 + FOXO4 |
| Specificity: |
This is a highly specific antibody against FOXO1 + FOXO3 + FOXO4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FOXO1 + FOXO3 + FOXO4 |
| Gene ID Number: |
2308 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death, FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway, FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein, FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes, It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1, It is also involved in negative regulation of the cell cycle, Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity, The specific function of the gene has not yet been determined, This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein, Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia, FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
AFX1 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the FOXO1 + FOXO3 + FOXO4 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
FOXO1 + FOXO3 + FOXO4 |
| Short name: |
FOXO1 + FOXO3 + FOXO4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, forkhead box O1 and forkhead box O3 and FOXO4 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AF6q21 and FKHRL1 and FKHRL1P2 and FOXO2 and FOXO3A, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006417 and regulation of translation and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0016020 and membrane and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030330 and DNA damage response, DNA-templated and biological process this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006473 and protein acetylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009267 and cellular response to starvation and biological process this GO :0010508 and positive regulation of autophagy and biological process this GO :0031018 and endocrine pancreas development and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0032873 and negative regulation of stress-activated MAPK cascade and biological process this GO :0034599 and cellular response to oxidative stress and biological process this GO :0035947 and regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0045599 and negative regulation of fat cell differentiation and biological process this GO :0045722 and positive regulation of gluconeogenesis and biological process this GO :0045732 and positive regulation of protein catabolic process and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0051721 and protein phosphatase 2A binding and molecular function this GO :0070417 and cellular response to cold and biological process this GO :0071455 and cellular response to hyperoxia and biological process this GO :0071732 and cellular response to nitric oxide and biological process this GO :2000505 and regulation of energy homeostasis and biological process, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process, FKH1 and FKHR and FOXO1A, FOXO1 and IDBG-26475 and ENSG00000150907 and 2308, FOXO1 and IDBG-629639 and ENSBTAG00000044105 and 506618, FOXO3 and IDBG-631758 and ENSBTAG00000011234 and 535530, FOXO3 and IDBG-95024 and ENSG00000118689 and 2309, Foxo1 and IDBG-143370 and ENSMUSG00000044167 and 56458, Foxo3 and IDBG-147382 and ENSMUSG00000048756 and 56484, forkhead box O3, nuclei, nuclei, protein phosphatase 2A binding, sequence-specific DNA binding, signal transduction by p53 class mediator and biological process this GO :0031490 and chromatin DNA binding and molecular function this GO :0034599 and cellular response to oxidative stress and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045648 and positive regulation of erythrocyte differentiation and biological process this GO :0045893 and positive regulation of transcription, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000989 and transcription factor binding transcription factor activity and molecular function this GO :0001078 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and molecular function this GO :0001568 and blood vessel development and biological process this GO :0001659 and temperature homeostasis and biological process this GO :0001678 and cellular glucose homeostasis and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001047 and core promoter binding and molecular function this GO :0001221 and transcription cofactor binding and molecular function this GO :0001542 and ovulation from ovarian follicle and biological process this GO :0001544 and initiation of primordial ovarian follicle growth and biological process this GO :0001547 and antral ovarian follicle growth and biological process this GO :0001556 and oocyte maturation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0000989 : transcription factor binding transcription factor activity, this GO :0000989 : transcription factor binding transcription factor activity and also this GO :0001078 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0051721 : protein phosphatase 2A binding, this GO :0001047 : core promoter binding, this GO :0001047 : core promoter binding and also this GO :0001221 : transcription cofactor binding and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0019901 : protein kinase binding and also this GO :0031490 : chromatin DNA binding and also this GO :0043565 : sequence-specific DNA binding, this GO :0001078 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, this GO :0001221 : transcription cofactor binding, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding, this GO :0003682 : chromatin binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0019901 : protein kinase binding, this GO :0031490 : chromatin DNA binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0043565 : sequence-specific DNA binding, this GO :0043565 : sequence-specific DNA binding, this GO :0051721 : protein phosphatase 2A binding, forkhead box O1 |
| Identity: |
7139 |
| Gene: |
FOXO4 |
More about : FOXO4 |
| Long gene name: |
forkhead box O4 |
| Synonyms gene: |
MLLT7 |
| Synonyms gene name: |
7 , 7 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog), translocated to, translocated to |
| Locus: |
Xq13, 1 |
| Discovery year: |
1994-12-14 |
| Entrez gene record: |
4303 |
| Pubmed identfication: |
7529552 |
| RefSeq identity: |
NM_005938 |
| Classification: |
Forkhead boxes |
| Havana BLAST/BLAT: |
OTTHUMG00000021789 |
| Locus Specific Databases: |
Mental Retardation database |