| Long name: |
FMR1 Primary Polyclonal Antibody |
| Also known as: |
FMR1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FMR1 |
| Specificity: |
This is a highly specific antibody against FMR1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FMRP |
| Gene ID number: |
2332 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
FMR1 localizes to both the nucleus and the cytoplasm and can also interact with two fragile X syndrome related factors, FXR1 and FXR2, In fragile X syndrome this tandem repeat is substantially amplified and subjected to extensive methylation and enhanced transcriptional silencing, It contains several features that are characteristics of RNA-binding proteins, Since FMR1 contains both a nuclear localization signal and a nuclear export signal it is also implicated in the nucleocytoplasmic transport of mRNAs, The FMR1 gene contains a distinct CpG dinucleotide repeat located in the 5' untranslated region of the gene, The FMR1 protein (or FMRP) is an RNA-binding protein that associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle, including two hnRNPK homology (KH) domains and an RGG amino acid motif (RGG box), which form heterodimers through their N-terminal coiled-coil domains, Fragile X syndrome is the most frequent form of inherited mental retardation and is the result of transcriptional silencing of the FMR1 gene on the X chromosome |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
FMR1, FMR1_HUMAN, FMRP, FMRP1, FRAXA, Fragile X mental retardation 1, Fragile X mental retardation 1 protein, POF, POF1, Protein FMR-1, Protein FMR1, FMR 1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FMR1 |
| Short name: |
FMR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FMR1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3775 |
| Gene: |
FMR1 |
More about : FMR1 |
| Long gene name: |
fragile X mental retardation 1 |
| Synonyms gene: |
POF1 POF |
| Synonyms gene name: |
premature ovarian failure 1 |
| Synonyms: |
FMRP FRAXA MGC87458 |
| Locus: |
Xq27, 3 |
| Discovery year: |
1992-01-17 |
| GenBank acession: |
X69962 |
| Entrez gene record: |
2332 |
| Pubmed identfication: |
1572655 |
| RefSeq identity: |
NM_002024 |
| Havana BLAST/BLAT: |
OTTHUMG00000022606 |
| Locus Specific Databases: |
Mental Retardation database LRG_762 |